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research Anti-androgenic potential of the fruit extracts of certain Egyptian Sabali> species and their genetic variability studies: a metabolomic-molecular modeling approach

1 citations , January 2022 in “Food & Function”

Certain Egyptian Sabal fruit extracts may help treat anti-androgenic diseases like benign prostatic hyperplasia.

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production
124 citations , March 2012 in “JAMA”

Testosterone's muscle-building effects do not require its conversion to DHT.

research Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature
14 citations , January 2020 in “Archivio Italiano di Urologia e Andrologia”

Finasteride helps with prostate symptoms but may cause sexual side effects.

research Association of breast cancer in men with exposure to 5-α reductase inhibitors: A RADAR report.
May 2012 in “Journal of Clinical Oncology”

Taking 5-alpha reductase inhibitors might be linked to breast cancer in men.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE
90 citations , October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research Curcuma aeruginosai>, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study
34 citations , July 2011 in “Journal of Dermatological Treatment”

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

research An update on the use of 5alpha-reductase inhibitors
7 citations , January 2004 in “Drugs of today”

5alpha-reductase inhibitors help treat hair loss and prostate issues but may cause sexual side effects.

research The connection of 5-alpha reductase inhibitors to the development of depression
4 citations , August 2021 in “Biomedicine & Pharmacotherapy”

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

research 5-Alpha-Reductase Inhibitors in the Treatment of Male Androgenetic Alopecia: Clinical Experience
September 2024 in “Health of Man”

Low-dose dutasteride effectively and safely promotes hair growth in men with androgenetic alopecia.

research High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY 191704, a human type 1 5α-reductase inhibitor, in plasma
1 citations , March 1997 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.

research Comparative Efficacy of Oral and Topical 5-Alpha Reductase Inhibitors in Reducing Dihydrotestosterone levels across Men with Androgenetic Alopecia: A Network Meta-Analysis incorporating Post-Hoc Analyses of Randomized Clinical Trial Data
January 2026 in “Open Science Framework”

Oral and topical 5-alpha reductase inhibitors affect DHT levels and hair density differently in treating hair loss.

research Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)
67 citations , February 1997 in “Teratology”

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

research Finasteride is the main inhibitor of 5α-reductase activity in microdissected dermal papillae of human hair follicles
28 citations , February 1999 in “Archives of Dermatological Research”

Finasteride potentially treats hair loss by reducing DHT production.

research 5 Alpha-Reductase Inhibitory Potential of Solanum nigrum Effective for Management of Alopecia
January 2024

Solanum nigrum may help treat hair loss.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1
13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions
14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-αi>-Reductase in the Treatment of Androgenetic Alopecia
68 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.
7 citations , July 1995 in “PubMed”

Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.

research 705 Influence of 5a-Reductase Inhibitor (5-ARI) Usage on the Reproductive Function of Married Men
June 2018 in “The Journal of Sexual Medicine”

Finasteride does not negatively affect male reproductive function.

research Women Also Use 5α-Reductase Inhibitors—Reply
November 2017 in “JAMA internal medicine”

Women also use 5α-reductase inhibitors, and their effects differ from men.

research 5-alpha-reductase inhibitors are associated with reduced frequency of COVID-19 symptoms in males with androgenetic alopecia (vol 35, pg e243, 2021)
January 2021 in “Journal of The European Academy of Dermatology and Venereology”

Men with hair loss who take a certain type of medication may experience fewer COVID-19 symptoms.

research Health Promotion Potential of Vegetables Cultivated in Northern Thailand: A Preliminary Screening of Tannin and Flavonoid Contents, 5α-Reductase Inhibition, Astringent Activity, and Antioxidant Activities
10 citations , January 2017 in “Journal of Evidence-Based Complementary & Alternative Medicine”

Some vegetables from Northern Thailand show promise for health benefits, including hair loss treatment and antioxidant properties.

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2
9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

research Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves
July 2025 in “Molecules”

Teak leaf extract can help treat hair loss, and its effectiveness varies by geographic origin.

research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats
13 citations , December 2010 in “Pharmacology Biochemistry and Behavior”

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

research Efficacy and Tolerability of 6-Month Treatment with Tamsulosin Plus the Hexanic Extract of Serenoa repens versus Tamsulosin Plus 5-Alpha-Reductase Inhibitors for Moderate-to-Severe LUTS-BPH Patients: Results of a Paired Matched Clinical Study
6 citations , June 2022 in “Journal of Clinical Medicine”

Tamsulosin with Serenoa repens is as effective as with 5-alpha-reductase inhibitors but causes fewer side effects.

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-αi>-Reductase in the Treatment of Androgenetic Alopecia
65 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride
45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

research Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats
34 citations , September 2013 in “Urology”

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase
20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

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Research

research Anti-androgenic potential of the fruit extracts of certain Egyptian Sabali> species and their genetic variability studies: a metabolomic-molecular modeling approach

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

research Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature

research Association of breast cancer in men with exposure to 5-α reductase inhibitors: A RADAR report.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

research Curcuma aeruginosai>, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study

research An update on the use of 5alpha-reductase inhibitors

research The connection of 5-alpha reductase inhibitors to the development of depression

research 5-Alpha-Reductase Inhibitors in the Treatment of Male Androgenetic Alopecia: Clinical Experience

research High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY 191704, a human type 1 5α-reductase inhibitor, in plasma

research Comparative Efficacy of Oral and Topical 5-Alpha Reductase Inhibitors in Reducing Dihydrotestosterone levels across Men with Androgenetic Alopecia: A Network Meta-Analysis incorporating Post-Hoc Analyses of Randomized Clinical Trial Data

research Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)

research Finasteride is the main inhibitor of 5α-reductase activity in microdissected dermal papillae of human hair follicles

research 5 Alpha-Reductase Inhibitory Potential of Solanum nigrum Effective for Management of Alopecia

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-αi>-Reductase in the Treatment of Androgenetic Alopecia

research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.

research 705 Influence of 5a-Reductase Inhibitor (5-ARI) Usage on the Reproductive Function of Married Men

research Women Also Use 5α-Reductase Inhibitors—Reply

research 5-alpha-reductase inhibitors are associated with reduced frequency of COVID-19 symptoms in males with androgenetic alopecia (vol 35, pg e243, 2021)

research Health Promotion Potential of Vegetables Cultivated in Northern Thailand: A Preliminary Screening of Tannin and Flavonoid Contents, 5α-Reductase Inhibition, Astringent Activity, and Antioxidant Activities

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

research Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves

research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats

research Efficacy and Tolerability of 6-Month Treatment with Tamsulosin Plus the Hexanic Extract of Serenoa repens versus Tamsulosin Plus 5-Alpha-Reductase Inhibitors for Moderate-to-Severe LUTS-BPH Patients: Results of a Paired Matched Clinical Study

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-αi>-Reductase in the Treatment of Androgenetic Alopecia

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

research Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase