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Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men.

6 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

research Finasteride and the 5-Alpha Reductase Inhibitors

October 2025 in “CRC Press eBooks”

research 0192 Estrogenic effects of 5-alpha-reductase inhibitors in male androgenetic alopecia patients

July 2025 in “Journal of Investigative Dermatology”

research The use of 5 alpha-reductase in the era of minimally invasive surgical therapies (MISTs): Is it still valuable?

September 2024 in “Uro-Technology Journal”

research Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride

April 2020

Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.

23 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism

17 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia

2 citations , September 1997 in “Archives of Dermatology”

research Relative efficacy of minoxidil and 5-alpha-reductase inhibitors in the treatment of male androgenetic alopecia: protocol for a network meta-analysis study

1 citations , May 2021

Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

research Studies on Neurosteroids XXV. Influence of a 5.ALPHA.-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , January 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

2 citations , April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

research Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women

21 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men

9 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Theoretical Evaluation of Interaction of Some Dibenzo Derivatives on Both Androgen Receptor and 5-Alpha-Reductase Enzyme

research Theoretical evaluation of interaction of some dibenzo derivatives on both androgen receptor and 5α-reductase enzyme

5 citations , January 2022 in “Clinical cancer investigation journal”

Certain Dibenzo derivatives may help treat prostate cancer.

research Risk of estrogen-driven malignancies in females on 5-alpha reductase inhibitors

1 citations , November 2024 in “Archives of Dermatological Research”

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

May 2026 in “Mendeley Data”

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

May 2026 in “Mendeley Data”

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

April 2026 in “Mendeley Data”

research Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study

March 2026 in “Journal of the American Academy of Dermatology”

research Re: A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome

September 2018 in “The Journal of Urology”

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness

61 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Psychiatric Comorbidity Related to the Therapy of Male Androgenetic Alopecia Independent of the 5–Alpha Reductase Pathway

October 2021 in “Skin appendage disorders”

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

7 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

235 citations , September 2004 in “The Journal of urology/The journal of urology”

Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.

research GhDET2, a steroid 5α‐reductase, plays an important role in cotton fiber cell initiation and elongation

193 citations , June 2007 in “The Plant Journal”

GhDET2 is crucial for cotton fiber growth.

research The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention

147 citations , June 2011 in “New England journal of medicine/The New England journal of medicine”

5α-reductase inhibitors may prevent prostate cancer but could also raise the risk of more severe cancers.

A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

research A New Look at the 5?-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

124 citations , March 2012 in “JAMA”

Testosterone's muscle-building effects do not require its conversion to DHT.

research 9 Role of 5α-reductase in health and disease

101 citations , April 1994 in “Baillière's clinical endocrinology and metabolism”

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

research Association of Suicidality and Depression With 5α-Reductase Inhibitors

90 citations , March 2017 in “JAMA Internal Medicine”

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

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