76 citations
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September 1992 in “Endocrinology” The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.
6 citations
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August 1996 in “The Journal of Clinical Endocrinology and Metabolism” MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.
34 citations
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July 1993 in “PubMed”
21 citations
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January 2010 in “JOURNAL OF HEALTH SCIENCE” Abietic acid from pine resin can effectively inhibit testosterone 5α-reductase.
14 citations
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June 1995 in “The Journal of Clinical Endocrinology and Metabolism” 4 citations
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January 1982 in “Endocrinologia Japonica” Androgens regulate 5 alpha-reductase activity in hamster sebaceous glands.
October 2025 in “CRC Press eBooks” July 2025 in “Journal of Investigative Dermatology” September 2024 in “Uro-Technology Journal”
23 citations
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January 2001 in “Chemical & Pharmaceutical Bulletin” New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.
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October 1994 in “The Journal of Clinical Endocrinology and Metabolism” 2 citations
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September 1997 in “Archives of Dermatology”
5 citations
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January 2022 in “Clinical cancer investigation journal” Certain Dibenzo derivatives may help treat prostate cancer.
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April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.
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August 1992 in “The Journal of Clinical Endocrinology and Metabolism” 1 citations
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November 2024 in “Archives of Dermatological Research” May 2026 in “Mendeley Data” May 2026 in “Mendeley Data” April 2026 in “Mendeley Data” March 2026 in “Journal of the American Academy of Dermatology” September 2018 in “The Journal of Urology” 61 citations
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September 1994 in “The Journal of Clinical Endocrinology and Metabolism” October 2021 in “Skin appendage disorders” 7 citations
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August 1996 in “The Journal of Clinical Endocrinology and Metabolism”
124 citations
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March 2012 in “JAMA” Testosterone's muscle-building effects do not require its conversion to DHT.
78 citations
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January 2000 in “Gynecological Endocrinology” Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.
49 citations
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January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
29 citations
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July 2009 in “BJU international” Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.