research Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone
DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.
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research Oral Testosterone in Oil: Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men
Taking oral testosterone with finasteride or dutasteride doubles testosterone levels, and food slightly affects it.
research Torilin fromTorilis japonica,as a New Inhibitor of Testosterone 5α-Reductase
Torilin from Torilis japonica can inhibit testosterone 5α-reductase but is less effective than finasteride.
research Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths
PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.
research Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry
The method effectively measures drug impact on DHT levels in prostate treatments.
research Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System
Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.
research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors
Certain progesterone derivatives can inhibit enzymes and reduce androgenic activity, potentially affecting prostate growth.
research A high-performance liquid chromatography–tandem mass spectrometry assay of the androgenic neurosteroid 3α-androstanediol (5α-androstane-3α,17β-diol) in plasma
Testosterone increases 3α-androstanediol levels, which can be blocked by finasteride.
research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism
research Safety aspects of androgen treatment with 5α-dihydrotestosterone
DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.
research Pustular allergic contact dermatitis from topical minoxidil 5%
A man had an allergic reaction to minoxidil, which stopped after he discontinued use and started corticosteroids.
research Treatment of trichostasis spinulosa with 0.5-millisecond pulsed 755-nm alexandrite laser
The 755-nm alexandrite laser effectively and quickly treats trichostasis spinulosa with minimal pain and no side effects.
research In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
Ketoconazole increases finasteride's effectiveness and lifespan in the body.
research Efficacy and safety of oral minoxidil 5 mg daily during 24-week treatment in male androgenetic alopecia
Oral minoxidil improves hair growth in men with hair loss, but caution needed for those with heart issues.
research Invalidation of a commercially available human 5α-dihydrotestosterone immunoassay
The DHT immunoassay is unreliable due to high cross-reactivity with testosterone.
research Plasma androsterone/epiandrosterone sulfates as markers of 5α-reductase activity: Effect of finasteride in normal men
Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.
research Is there a role for 5α‐reductase inhibitors in transgender individuals?
5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.
research Treatment of androgenetic alopecia with a 7.5% herbal preparation
Herbal preparation effectively promotes hair growth and reduces hair loss.
research Greater conversion of testosterone to 5α-dihydrotestosterone, reflecting increased peripheral 5α-reductase activity in nude mice treated with high doses of cyclosporine A
High doses of cyclosporine A increase testosterone conversion, possibly boosting hair growth.
research Pathologic Quiz Case: An Anterior Neck Mass in a 5-Month-Old Female Infant
The neck mass was a rare benign "wattle," surgically removed for diagnosis and appearance.
research Comparative GC-MS Based In vitro Assays of 5α-Reductase Activity Using Rat Liver S9 Fraction
The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.
research Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study
Cetirizine 1% helps hair growth in men with no major side effects, but minoxidil 5% works better.
research Frontal edema due to topical application of %5 minoxidil solution following mesotherapy injections
Applying minoxidil on the scalp after mesotherapy injections caused temporary swelling.
research The use of topical ruxolitinib 1.5% cream in frontal fibrosing alopecia: A case report
Topical ruxolitinib cream may help treat frontal fibrosing alopecia.
research Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-aza-5-androstene-17-carboxylate, A Key Intermediate for Finasteride and Dutasteride
Alcoholic solvent improves selectivity in key intermediate for finasteride and dutasteride synthesis.
research The Benefits of Dual Inhibition of 5α Reductase
Dutasteride reduces DHT and improves BPH symptoms more effectively than finasteride.
research The effects of garlic topical gel (5%) in the treatment of alopecia areata
Garlic gel can help hair grow in people with alopecia areata.
research Prospective cardiovascular evaluation with 24-hour Holter and 24-hour ambulatory blood pressure monitoring in men using 5-mg oral minoxidil for androgenetic alopecia
The conclusion is that 24 weeks of low-dose oral minoxidil is safe for men with hair loss, with no significant changes in heart rate or blood pressure.
research Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation
Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.
research Novel azaandrostane derivatives for the synthesis of 17β‐(N‐tert‐butyl carbamoyl)‐4‐aza‐5α‐androst‐1‐ene‐3‐one
A new method to make finasteride for hair loss treatment was developed.