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Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

Certain progesterone derivatives can inhibit enzymes and reduce androgenic activity, potentially affecting prostate growth.

Progesterone and its metabolites can prevent seizures without major side effects.

3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.

Canine hair follicle cells convert progesterone into various metabolites, mainly cortisol.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Progesterone affects GABA_A receptor function by altering δ subunit levels.

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

High doses of progesterone can reduce seizures in mice.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

Progesterone protects brain cells, but Provera does not.

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

Higher 3α,5α-THP levels in the brain may reduce depression in pregnant rats.

The compound was successfully made and shows potential for treating prostate cancer.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

A new, safer method to make finasteride from progesterone is effective for industrial use.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

Progesterone reduces anxiety and depression in female mice by increasing BDNF in the brain, needing 5α-reduction and estradiol.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

Blocking progesterone metabolism can cause depression-like behavior in mice.

The new compounds may be more effective and cheaper than current treatments for conditions like baldness.

New compounds may help treat prostate issues without affecting androgen receptors.

Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.