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Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

research Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2

8 citations , June 2017 in “Steroids”

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

research Inhibition of 5α-reductase in the rat prostate by Cimicifuga racemosa

7 citations , August 2006 in “Maturitas”

Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.

research The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles.

3 citations , December 2000 in “PubMed”

CS-891 may effectively treat hair loss by blocking enzymes in hair follicles.

research PD02-05 SRD5A2 EXPRESSION IS A PREDICTOR OF RESPONSE TO FINASTERIDE IN THE MTOPS TRIAL

March 2023 in “The Journal of Urology”

Higher SRD5A2 expression predicts better response to finasteride in treating urinary symptoms.

5α-Reductase Inhibitors: Progress and Therapeutic Potential

research 5α-reductase inhibitors

5 citations , January 2001 in “Advances in protein chemistry”

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

research FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects

17 citations , June 1996 in “The Journal of Steroid Biochemistry and Molecular Biology”

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors: Review Article for Pharmacists and Healthcare Professionals

research Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals

July 2025

5α-reductase inhibitors help treat prostate enlargement and hair loss but may cause side effects, requiring careful use.

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