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Hair cortisol concentration partly reflects HPA axis regulation but doesn't capture all its complexities.

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.

Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.

Human hair follicles can produce stress hormones like the body's main stress response system.

5α-reductases increase epitestosterone's effect on androgen receptors.

Hair cortisol can indicate animal stress but varies with many factors.

Childhood sexual trauma, especially between ages 5-7, is linked to lower cortisol levels in adult hair, suggesting long-term stress response changes.

The study found no significant difference in stress hormone levels between people with alopecia areata and healthy individuals, suggesting that the disease is not caused by an overactive stress response system.

The treatment reduced hair growth and testosterone in women with excess hair and had some effects on stress responses.

Intramuscular triamcinolone and pulse therapy with oral predonine are effective for alopecia areata with manageable side effects, but better relapse prevention is needed.

Hair cortisol can be used to measure long-term stress exposure.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Untreated congenital adrenal hyperplasia can lead to complications like stroke and needs glucocorticoid treatment.

The new method can measure sleep-related hormones in hair effectively and could help track long-term sleep patterns.

The woman had a rare adrenal tumor removed, and she recovered well with no signs of the tumor returning.

A woman's excessive hair growth was caused by a rare benign tumor in her adrenal gland, which was successfully removed.

Topical corticosteroids can cause serious side effects like Cushing's syndrome and hirsutism.

Human adrenals and gonads have a unique enzyme for steroid hormone production.

Depressed teens have different steroid levels in urine, which may help identify and treat them.

A woman's rare benign tumor that released both cortisol and testosterone was successfully removed, improving her health.

A new method accurately measures steroid hormones in a few hair strands and could help study chronic stress and hair loss.

A woman's hair loss and other symptoms were due to a rare hormone deficiency treatable with steroids.

The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.

Compound 15a was effective in inhibiting 5α-reductase.

The rapid corticotropin test is a quick and simple way to diagnose adrenal insufficiency.

A 300 mg monthly pulse of prednisolone effectively and safely treats widespread alopecia areata.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.