Search

for
Search:

Did you mean Steroid 5 Alpha-Reductase 2?

GlossarySteroid 5 Alpha-Reductase 2

enzyme converting testosterone to potent androgen dihydrotestosterone (DHT)

Steroid 5 Alpha-Reductase 2 (also known as 5α-Reductase Type 2 or SRD5A2) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen. This enzyme plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and benign prostatic hyperplasia.

Related Terms

Sort by

Research

30 / 1000+ results

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Screen steroid 5 alpha-reductase inhibitors in vitro by high performance liquid chromatography

January 2005 in “Fuzhou daxue xuebao. Ziran kexue ban”

The method is quick and effective for testing steroid 5 alpha-reductase inhibitors.

research Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors

April 1992 in “Current opinion in therapeutic patents”

New steroids were patented as effective for treating acne, hair loss, and other conditions related to hormones.

research Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors

14 citations , February 2018 in “Psychoneuroendocrinology”

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Intraethnic Variation in Steroid-5-Alpha-Reductase Polymorphisms in Prostate Cancer Patients: A Potential Factor Implicated in 5-Alpha-Reductase Inhibitor Treatment

research Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment

4 citations , June 2015 in “Journal of Genetics/Journal of genetics”

Genetic differences within ethnic groups may affect prostate cancer treatment effectiveness.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research Steroid 5α-reductase inhibition by polymethoxyflavones

6 citations , August 2013 in “한국응용생명화학회지”

Certain natural compounds can block an enzyme linked to prostate enlargement and hair loss, showing potential for new treatments.

Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

research Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur

November 2023 in “Scientific reports”

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

research Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men.

15 citations , June 1995 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect erections much, but may decrease libido in men.

research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors

13 citations , January 2017 in “Chemical & Pharmaceutical Bulletin”

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

Compound 15a was effective in inhibiting 5α-reductase.

Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines

research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines

3 citations , February 2021 in “Molecules”

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

research Screening of steroid 5-reductase inhibitory activity and total phenolic content of Thai plants

April 2011 in “Journal of Medicinal Plants Research”

Ocimum basilicum L. and red Oryza sativa L. may help with hair loss and prostate issues.

research GhDET2, a steroid 5α‐reductase, plays an important role in cotton fiber cell initiation and elongation

193 citations , June 2007 in “The Plant Journal”

GhDET2 is crucial for cotton fiber growth.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research Comprehensive Evaluation of Tectona grandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties

November 2025 in “ACS Omega”

Teak leaf extract may help hair growth and reduce inflammation safely.

research Comprehensive Evaluationof Tectonagrandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-ReductaseInhibition and Anti-Inflammatory Properties

November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Tectona grandis leaves may help treat hair loss and inflammation.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1

3 citations , June 2018 in “Bioorganic & medicinal chemistry”

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.

53 citations , June 1993 in “Proceedings of the National Academy of Sciences of the United States of America”

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells

January 2004 in “Pharmaceutical biotechnology”

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

72 citations , January 2011 in “Current Pharmaceutical Design”

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

research Subcellular localization of the five members of the human steroid 5α-reductase family

13 citations , June 2017 in “Biochimie open”

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

30 citations , October 2020 in “Nature Communications”

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

research Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer

30 citations , June 2010 in “Endocrine Related Cancer”

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

research Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates

21 citations , January 2020 in “General and Comparative Endocrinology”

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.