6 citations
,
October 2007 in “Medical Hypotheses” Male pattern baldness might have evolved to help protect against prostate cancer by increasing UV radiation on the scalp.
March 2024 in “The journal of sexual medicine” Finasteride's negative effects on brain tissue in male rats may be reversible after stopping the drug.
47 citations
,
September 2016 in “Reviews in endocrine and metabolic disorders” The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.
17 citations
,
February 2019 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
2 citations
,
April 2018 in “Natural Product Communications” Cynomorium songaricum has many health benefits and could help with hair regrowth.
1 citations
,
January 2012 in “Daehan namseong gwahag hoeji” Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.
September 2025 in “International Journal of Innovative Technologies in Social Science” Dutasteride is more effective than finasteride for hair loss, but more research is needed on safety and dosing.
June 2024 in “Ecotoxicology and Environmental Safety” Finasteride harms Daphnia magna's reproduction, growth, and metabolism.
November 2023 in “Expert Opinion on Pharmacotherapy” Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.
January 2018 in “Surgical and Cosmetic Dermatology” Finasteride and dutasteride are effective for male hair loss and enlarged prostate but may cause reversible sexual side effects.
408 citations
,
May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.
153 citations
,
March 2017 in “Endocrine” Male pattern baldness involves genetics, hormones, and needs better treatments.
46 citations
,
September 2011 in “Journal of Endocrinology” Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
44 citations
,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
35 citations
,
October 2011 in “Medicine and science in sports and exercise” Muscles can make their own androgens, which may help muscle growth.
30 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
11 citations
,
February 2016 in “Current Medicinal Chemistry” New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
11 citations
,
August 1997 in “Expert Opinion on Therapeutic Patents” Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.
4 citations
,
April 1999 in “Dermatologic Clinics” Androgens, like DHT, affect hair growth and treatments like finasteride may help.
3 citations
,
June 2018 in “Bioorganic & medicinal chemistry” Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.
1 citations
,
January 2008 in “Actas Dermo-Sifiliográficas” Treat hair loss in postmenopausal women with diet, avoiding certain drugs, and using medications like minoxidil or finasteride.
November 2012 in “Endocrine Practice” Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
October 2006 in “Aging Health” Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.
131 citations
,
August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
343 citations
,
October 2015 in “Endocrine Practice” The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.
35 citations
,
January 2012 in “The Journal of Sexual Medicine” Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.
5 citations
,
January 2018 in “Interdisciplinary sciences: computational life sciences” Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.
71 citations
,
September 2007 in “Cancer” Prostate cancer prevention includes diet changes, supplements, and medications, with more answers expected soon.
59 citations
,
March 2020 in “Journal of Biomedical Science” Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
32 citations
,
August 1999 in “Journal of Investigative Dermatology” Early onset hair loss linked to genetics and androgen levels.