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Testosterone needs to be converted to DHT to reduce stress response in male rats.

Increasing Rps14 helps grow more inner ear cells and repair hearing cells in baby mice.

5α-reductase inhibitors like finasteride and dutasteride can help treat skin disorders stimulated by androgens, such as hair loss and acne.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Runx1 helps control the KAP5 gene in human hair follicles.

FOL-005, a hair growth promoter, acts locally on mouse skin where injected and could be a promising hair loss treatment.

Human adrenals and gonads have a unique enzyme for steroid hormone production.

The combination of oral minoxidil, oral dutasteride, and mesotherapy is the most effective and safe for hair growth in AGA.

Dihydrotestosterone (DHT) and its active metabolites play a key role in various diseases, and the development of 5α-reductase inhibitors can help treat these conditions.

RORA plays a key role in controlling seasonal hair molting by affecting hair follicle cell activity.

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

The Fas/FasL pathway may play a role in alopecia areata.

Male pattern baldness is likely caused by multiple genes, not just 5α-reductase genes.

HA-P5 effectively treats acne without causing side effects seen in other treatments.

5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.

The compound 4c effectively inhibits the enzyme linked to hair loss.

Vitamin B5 and coenzyme A may help regulate the immune system and could improve treatments for chronic diseases and cancer.

Blocking a certain signal in the gp130 receptor can improve tissue healing and lessen osteoarthritis symptoms.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.

Finasteride is made through a series of chemical reactions starting from a specific intermediate compound.