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Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

research Discovery and Clinical Development of Dutasteride, a Potent Dual 5α- Reductase Inhibitor

58 citations , March 2006 in “Current topics in medicinal chemistry”

Dutasteride effectively treats benign prostatic hyperplasia and may reduce prostate cancer risk.

research 5α-Reductase Inhibitors Do Not Prevent the Development and Progression of Urothelial Cancer: In Vitro Evidence

3 citations , September 2020 in “Bladder cancer”

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

research A new label-free screen for steroid 5α-reductase inhibitors using LC-MS

15 citations , October 2016 in “Steroids”

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review

35 citations , April 2013 in “Sexual medicine reviews”

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

research 5 alpha-reductase inhibition by a new synthetic steroid (PM-9) in cultures of Penicillium crustosum.

1 citations , January 2002 in “PubMed”

PM-9, like finasteride, may help treat certain diseases by blocking a key enzyme.

Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase

research Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase

29 citations , July 2009 in “BJU international”

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

The Effect of 5-Alpha Reductase Inhibitor on Male Reproductive Function

research (379) The Effect of 5-α Reductase Inhibitor on Male Reproductive Function

February 2024 in “The Journal of Sexual Medicine”

5-α reductase inhibitors do not significantly affect male reproductive function but may reduce semen volume.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

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