research Drug Repurposing against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study
Afatinib, neratinib, and zanubrutinib could be effective against KRASG12C-mutant tumors.
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research Nanomaterials in hair care and treatment
Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.
research Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability
Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.
research A Natural Inhibitor, 1′S-1′-Acetoxychavicol Acetate, Against Testosterone-Induced Alopecia via NADPH Oxidase Regulation
1′S-1′-Acetoxychavicol acetate may help treat hair loss by reducing oxidative stress.
research Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway
Water extract of Cacumen Platycladi helps hair growth by activating specific cell pathways.
research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss
Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.
research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate
Scientists made two new chemicals that might help treat diseases caused by male hormones.
research Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair‐growing agent
Apple procyanidin applied to the scalp may help grow hair without side effects.
research Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway
Morroniside may help hair grow and stay in its growth phase by affecting certain cell signals.
research Phospholipid–polymer hybrid nanoparticle-mediated transfollicular delivery of quercetin: prospective implement for the treatment of androgenic alopecia
Quercetin-loaded nanoparticles can penetrate skin, minimize hair loss, and promote hair regrowth, showing slightly better results than a marketed product.
research The effects of Glehnia littoralis and Andrographis paniculata extract on hair growth in human follicle dermal papilla cells
Glehnia littoralis and Andrographis paniculata extracts can significantly boost hair growth.
research HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth
HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.
research General Dermatology
The document explains various skin conditions and their treatments.
research Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies
Resveratrol-loaded nanovesicles effectively promote hair growth and treat hair loss.
research Effects of Nannochloropsis salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth
Nannochloropsis salina fermented oil may help treat hair loss by promoting hair growth and reducing oxidative stress.
research ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
ISX9 helps regrow hair by activating a specific cell signaling pathway.
research Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health
DA-5512 effectively improves hair growth and health, performing better than minoxidil.
research Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice
Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
research A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study
Limelight (CB-EVs) safely promotes hair growth.
research Signalling by senescent melanocytes hyperactivates hair growth
Senescent melanocytes can boost hair growth by activating hair stem cells.
![Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase](/images/research/d91300a7-4d66-4d2c-90ac-293b0dbc5ff5/small/21048.jpg)
research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase
Compound 15a was effective in inhibiting 5α-reductase.
research Towards a consensus on how to diagnose and quantify female pattern hair loss – The ‘Female Pattern Hair Loss Severity Index (FPHL-SI)’
New method measures female hair loss: Female Pattern Hair Loss Severity Index (FPHL-SI).
research Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
PLGA-based microneedles are promising for safe and effective skin delivery of drugs and vaccines.
research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone
New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.
research Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin
PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.
![The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route](/images/research/73bab8dc-bdf0-45e3-8ef7-73d0d4b93cb1/small/21074.jpg)
research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route
Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.
research Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose
2-deoxy-D-ribose gel may help regrow hair in cases of hair loss.
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
New compounds called benzoquinolinones may treat conditions linked to excess DHT.
research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
research A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice
A mix of tocopherol acetate and L-menthol helps grow hair better than using them separately or using minoxidil.