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research Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss

33 citations , February 2021 in “Journal of Medicinal Chemistry”

The study reported the synthesis and evaluation of novel analogues of UK-5099 as mitochondrial pyruvate carrier (MPC) inhibitors to treat hair loss. Researchers explored the structure–activity relationship by modifying four positions of the hit compound. They discovered that inhibitors with a 3,5-bis(trifluoromethyl)benzyl group at the N1 position showed superior activity compared to JXL001 (UK-5099) in increasing cellular lactate production. Analogue JXL069, featuring a 7-azaindole heterocycle, also demonstrated significant MPC inhibition, expanding the potential for drug design. Over 10 analogues were tested on shaved mice through topical treatment, resulting in noticeable hair growth.

research Recent updates on Wnt signaling modulators: a patent review (2014-2020)

14 citations , June 2021 in “Expert Opinion on Therapeutic Patents”

New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

8 citations , July 2024 in “Journal of Advanced Research”

CDK inhibitors may help treat ARDS and psoriasis but need more testing for safety and effectiveness.

Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota

research Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota

14 citations , January 2020 in “International Journal of Biological Sciences”

Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.

research Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter

April 2024 in “Journal of translational medicine”

MJ04, a new compound, effectively promotes hair growth and is a potential topical treatment for hair loss.

research 7 Regulation of androgen receptor and 5α-reductase in the skin of normal and hirsute women

35 citations , May 1986 in “Clinics in endocrinology and metabolism”

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

research 7-Phloroeckol promotes hair growth on human follicles in vitro

17 citations , May 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology”

7-Phloroeckol from brown algae may help hair grow.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research 7 Aesthetic Facial Proportions

1 citations , January 2016 in “Georg Thieme Verlag eBooks”

The document concludes that ideal facial proportions are guided by specific measurements and symmetry to enhance beauty, but individual characteristics must be considered.

research (7E)-7,8-Dehydroheliobuphthalmin from Platycladus orientalis L.: Isolation, Characterization, and Hair Growth Promotion

May 2025 in “International Journal of Molecular Sciences”

DHHB from Platycladus orientalis L. promotes hair growth and could be a natural alternative to current treatments.

Microneedling and Platelet-Rich Plasma: A 2018 Study on Effectiveness for Skin and Hair Conditions

research 7 Microneedling and Platelet-Rich Plasma

January 2018

Combining microneedling with platelet-rich plasma enhances skin repair and collagen production but may not offer significant extra benefits.

Comparative Study of the Insect Repellency Action of Over-the-Counter Herbal Insect Repellent Lotions Against 7.5% DEET Lotion

research Comparative study the insect repellency action of over the counter herbal insect repellents lotions against 7.5% DEET lotion

June 2017 in “Journal of The American Academy of Dermatology”

7.5% DEET lotion is more effective and safe at repelling mosquitoes than rosemary, citronella, and lemongrass lotions.

Surgery and Laser Treatments in Dermatology

research 7. Surgery and Laser

April 2003 in “Journal of Cutaneous Medicine and Surgery”

Lasers are effective for some skin conditions but can cause side effects like scarring and pigment changes; careful selection is important, and botulinum toxin type A is successful in reducing sweat in palmar hyperhidrosis.

research 7 Pathogenesis and Classification of Male Pattern Hair Loss (Androgenic Alopecia)

October 2022 in “Hair Transplantation”

Male pattern hair loss is mainly caused by genetics and hormones, especially DHT.

research Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

245 citations , October 2015 in “Nature medicine”

Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , March 2013 in “The journal of immunology/The Journal of immunology”

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Identification of the Rat Rex Mutation as a 7-bp Deletion at Splicing Acceptor Site of the Krt71 Gene

45 citations , January 2010 in “Journal of Veterinary Medical Science”

A gene mutation causes curly hair and hair loss in rats.

research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells

39 citations , August 2022 in “Pharmaceutics”

Combining letrozole and quercetin in spanlastics may improve breast cancer treatment.

research SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice

38 citations , July 2020 in “EMBO journal”

SIRT7 protein is crucial for starting hair growth in mice.

research Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse

35 citations , October 2002 in “Biochemical and Biophysical Research Communications”

The research cloned keratin 7 genes from humans, mice, and marsupials, found similarities between human and mouse genes, and discovered new areas of K7 expression in mice.

research Chapter 7 Reproductive Dysfunction in Women with Epilepsy

34 citations , January 2008 in “International Review of Neurobiology”

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research hKAP1.6 and hKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins are Expressed in the Hair Follicle Cortex

24 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Two new proteins, hKAP1.6 and hKAP1.7, are found in the hair follicle cortex.

research Testosterone Induces Increase in Aquaporin (AQP)-1, 5, and 7 Expressions in the Uteri of Ovariectomized Rats

23 citations , July 2015 in “The Journal of Membrane Biology”

Testosterone increases certain proteins in the uterus, reducing fluid volume.

research Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7

13 citations , July 2016 in “BMC Complementary and Alternative Medicine”

Hominis Placenta helps hair grow back by increasing cell growth and a specific growth factor.

research Effects of testosterone on mean arterial pressure and aquaporin (AQP)-1, 2, 3, 4, 6 and 7 expressions in the kidney of orchidectomized, adult male Sprague-Dawley rats

9 citations , January 2017 in “Archives of biochemistry and biophysics”

Testosterone raises blood pressure and changes kidney protein levels.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

research Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

7 citations , January 2019 in “Pharmaceutical Biology”

Eclipta prostrata helps hair growth and maintains the growth phase by affecting certain growth factors.

Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

research Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

6 citations , August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.