551 citations
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November 2013 in “Nature” Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.
550 citations
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January 2012 in “Oxford University Research Archive (ORA) (University of Oxford)” Lithium can cause some health issues, but severe risks are low.
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February 2008 in “PLANT PHYSIOLOGY” OsPHR2 gene causes excessive phosphate in rice shoots, affecting plant growth and root development.
532 citations
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August 2011 in “Journal of the American Academy of Dermatology” Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.
527 citations
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December 2011 in “Proceedings of the National Academy of Sciences” Dextran hydrogels improve burn wound healing and skin regeneration.
522 citations
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January 2001 in “Cancer investigation” Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
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January 2017 in “AIMS biophysics” Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.
520 citations
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February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
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February 2020 in “Inflammation and Regeneration” RANKL is crucial for bone health, immune function, and other body processes.
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October 1998 in “Endocrinology” Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.
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November 2014 in “Science” Skin grafting and wound treatment have improved, but we need more research to better understand wound healing and create more effective treatments.
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February 2010 in “Materials” Keratin from hair and wool is used in medical materials for healing and drug delivery.
515 citations
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April 2003 in “Endocrine Reviews” Androgens and DHEA can help prevent breast cancer and improve health in women.
512 citations
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February 2008 in “Science” Reactive oxygen species and calcium create a feedback loop that shapes root hair cells.
510 citations
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August 2006 in “Endocrinology” The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.
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June 2009 in “Current drug metabolism” Tyrosine kinase inhibitors effectively treat cancers but often cause skin and other side effects.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
506 citations
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January 2012 in “Molecular and Cellular Endocrinology” Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
506 citations
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March 2005 in “The Journal of Clinical Endocrinology and Metabolism” Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.
505 citations
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October 2011 in “Journal of clinical oncology” MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
503 citations
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May 2009 in “Cell stem cell” Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.
502 citations
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February 2008 in “The Journal of Clinical Endocrinology & Metabolism” Treat significant hirsutism with medication and hair removal; use birth control pills first, adding antiandrogens if needed.
501 citations
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October 2008 in “Psychoneuroendocrinology” Hair cortisol levels can show increased stress during late pregnancy but only for up to six months.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
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July 2000 in “The Journal of Clinical Endocrinology and Metabolism” Polycystic ovary syndrome is found in 6.5% of unselected Caucasian women in Spain.
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November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
489 citations
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June 2005 in “The FASEB Journal” Human hair follicles can produce cortisol like the body's stress response system.
488 citations
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July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
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June 1979 in “Proceedings of the National Academy of Sciences” Keratins provide structural strength in epithelial cells and help identify cell origins.