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research Identification of Novel Mutations in Basic Hair Keratins hHb1 and hHb6 in Monilethrix: Implications for Protein Structure and Clinical Phenotype

62 citations , October 1999 in “Journal of Investigative Dermatology”

New mutations in hair keratin genes can change hair structure and cause monilethrix, with nail issues more common in certain gene mutations.

research A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type

60 citations , March 2006 in “Journal of Medical Genetics”

A mutation in the KRTHB5 gene causes hair and nail issues.

research Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization.

59 citations , August 1981 in “PubMed”

Trichilemmal keratinization is a unique process in hair follicles where the outer root sheath turns into keratin without a specific layer.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes

57 citations , June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues.

57 citations , January 1987 in “Journal of Biological Chemistry”

Different keratins have unique expression patterns in mouse skin cells.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

research Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle

55 citations , September 2003 in “Experimental Dermatology”

PDGF signaling may play a role in hair growth cycle regulation.

research Endocrine controls of keratin expression

54 citations , March 2009 in “BioEssays”

Hormones control keratin production in skin and hair.

research Skin Keratins

54 citations , November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Keratins are important for skin cell health and their problems can cause diseases.

research A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13

54 citations , January 1995 in “Human Molecular Genetics”

Monilethrix is linked to a gene cluster on chromosome 12.

research The keratins and their disorders

53 citations , September 2004 in “American journal of medical genetics. Part C, Seminars in medical genetics”

Mutations in keratin genes cause cell fragility and various skin disorders.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology”

K16 can partially replace K14 but causes hair loss and skin issues.

research Characterization of the Human Hair Keratin–Associated Protein 2 (KRTAP2) Gene Family

52 citations , April 2012 in “Journal of Investigative Dermatology”

KRTAP2 genes are crucial for hair structure and may impact hair disorders and treatments.

research Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes

52 citations , October 1995 in “Experimental Cell Research”

Human hair keratin genes hHa2 and hHb1 are located on chromosomes 17 and 12.

Hair Growth Induction by the Tellurium Immunomodulator AS101: Association with Delayed Terminal Differentiation of Follicular Keratinocytes and Ras-Dependent Up-Regulation of KGF Expression

research Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression

51 citations , December 2003 in “The FASEB Journal”

The substance AS101 can help hair grow by slowing down hair cell aging and boosting a hair growth protein.

research Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes

49 citations , March 2004 in “Journal of Investigative Dermatology”

The hHa7 gene is regulated by androgens in certain body hair, not scalp hair.

research A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11

49 citations , October 1989 in “Genomics”

Type I keratin genes are closely linked to the rex locus on mouse chromosome 11, affecting hair development.

research Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter

47 citations , January 1998 in “Molecular Carcinogenesis”

ErbB2 signaling is crucial for skin cell growth and cancer development in mice.

research Significance of stress keratin expression in normal and diseased epithelia

47 citations , January 2024 in “iScience”

Stress keratins are expressed less in diseased skin and are linked to differentiation, inflammation, and immunity.

research Structure–property relationships of meta-kerateine biomaterials derived from human hair

47 citations , September 2011 in “Acta biomaterialia”

Protein composition greatly affects the function of keratin biomaterials.

research A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.

46 citations , May 1995 in “Proceedings of the National Academy of Sciences”

A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.

research Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells

46 citations , August 2012 in “Experimental Dermatology”

Engineered skin can grow chimeric hair follicles only with mouse dermal papilla cells.

research Hair Keratin: Composition, Structure and Biogenesis

45 citations , January 1986

research A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse

44 citations , March 2012 in “Molecular Carcinogenesis”

Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.

research Embryonic keratinization in vertebrates in relation to land colonization

44 citations , May 2008 in “Acta Zoologica”

Keratinization in embryos helped vertebrates adapt to land by forming a protective skin barrier.

research Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress

43 citations , August 2016 in “International Journal of Nanomedicine”

Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.

research Increased rate of hair keratin gene loss in the cetacean lineage

42 citations , January 2014 in “BMC Genomics”

Cetaceans lost hair genes to adapt to water.

research Cultured Keratinocyte Sheets Enhanced Spontaneous Re-Epithelialization in a Dermal Explant Model of Partial-Thickness Wound Healing

42 citations , September 1990 in “Journal of Investigative Dermatology”

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations , May 2020 in “Frontiers in immunology”

Hidradenitis suppurativa might be a type of autoinflammatory skin disease.

research Brazilian keratin hair treatment: a review

40 citations , June 2013 in “Journal of cosmetic dermatology”

Brazilian keratin treatments can straighten hair but may contain harmful formaldehyde.

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