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Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

research Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

November 2023 in “Life”

Eriocitrin and silymarin might be effective for hair loss treatment and need more research.

In Search of Predictive Models for Inhibitors of 5-Alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data

research In Search of Predictive Models for Inhibitors of 5-alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data.

January 2014 in “IWBBIO”

The models can help find better inhibitors for conditions like baldness and prostate disorders.

research Re: Inhibitors of 5α-Reductase-Related Side Effects in Patients Seeking Medical Care for Sexual Dysfunction

December 2013 in “The Journal of Urology”

research Torilin fromTorilis japonica,as a New Inhibitor of Testosterone 5α-Reductase

22 citations , May 2003 in “Planta Medica”

Torilin from Torilis japonica can inhibit testosterone 5α-reductase but is less effective than finasteride.

research Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibitor, in men with male pattern hair loss

46 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.

research Finasteride, a Type 2 5α-reductase inhibitor, in the treatment of men with androgenetic alopecia

32 citations , April 1999 in “Expert Opinion on Investigational Drugs”

Finasteride effectively treats male hair loss, improving growth and density.

research Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

29 citations , April 2019 in “BMJ. British medical journal”

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

research Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo

18 citations , February 2021 in “Archives of Dermatological Research”

Physcion may help treat hair loss by blocking an enzyme linked to baldness.

Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations , December 2018 in “Assay and Drug Development Technologies”

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

6 citations , March 2003 in “Archiv Der Pharmazie”

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

research Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2

5 citations , November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.

A 5α-Reductase Inhibitor, Finasteride, Increases Differentiation and Proliferation of Embryonal Carcinoma Cell-Derived Neural Cells

research A 5α-reductase inhibitor, finasteride, increases differentiation and proliferation of embryonal carcinoma cell-derived-neural cells

4 citations , September 2010 in “Medical Hypotheses”

research The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

2 citations , September 2009 in “Hormone Molecular Biology and Clinical Investigation”

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

research Role of 5α-reductase inhibitors in Parkinson's disease: Gambling or not?

June 2026 in “The Journal of Steroid Biochemistry and Molecular Biology”

research Finasteride and the 5-Alpha Reductase Inhibitors

October 2025 in “CRC Press eBooks”

research Re: Association of Treatment with 5α-Reductase Inhibitors with Time to Diagnosis and Mortality in Prostate Cancer

August 2019 in “The Journal of Urology”

Treatment with 5α-reductase inhibitors is linked to a delay in prostate cancer diagnosis and may affect survival rates.

Association of Breast Cancer in Men with Exposure to 5-Alpha Reductase Inhibitors: A RADAR Report

research Association of breast cancer in men with exposure to 5-α reductase inhibitors: A RADAR report.

May 2012 in “Journal of Clinical Oncology”

Taking 5-alpha reductase inhibitors might be linked to breast cancer in men.

research ChemInform Abstract: Rα‐Reductase Inhibitors‐ — The Finasteride Story

November 2011 in “ChemInform”

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase

11 citations , January 2000 in “The Journal of Steroid Biochemistry and Molecular Biology”

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

research Finasteride: the first 5 alpha-reductase inhibitor.

34 citations , July 1993 in “PubMed”

research Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine

9 citations , October 1993 in “The Journal of Clinical Pharmacology”

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

research Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat

4 citations , April 2009 in “Journal of Pain”

Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.

Ageratum Conyzoides L. Extract Inhibits 5α-Reductase Gene Expression and Prostaglandin D2 Release in Human Hair Dermal Papilla Cells and Improves Symptoms of Hair Loss in Healthy Males and Females in an Open Label Pilot Study

research Ageratum Conyzoides L. Extract Inhibits 5α-Reductase Gene Expression and Prostaglandin D2 Release in Human Hair Dermal Papilla Cells and Improves Symptoms of Hair Loss in Otherwise Healthy Males and Females in an Open Label Pilot Study

January 2021 in “Journal of cosmetology & trichology”

Ageratum conyzoides L. extract may effectively and safely treat hair loss.

research Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat

April 2009 in “Journal of Pain”

Finasteride reduces pain in male rats and works better with testosterone.

research Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht.

February 1996 in “Clinical Pharmacology & Therapeutics”

MK-386 reduces sebum DHT levels.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition

37 citations , September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

research Kaempferol Rhamnosides from Geranium sibiricum as Aldose Reductase Inhibitors and Their Content by HPLC Analysis

4 citations , June 2020 in “Processes”

Geranium sibiricum may help manage diabetic complications by inhibiting a key enzyme.

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