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720-750 / 1000+ resultsresearch Psychiatric Comorbidity Related to the Therapy of Male Androgenetic Alopecia Independent of the 5–Alpha Reductase Pathway
research Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5α-reductase inhibitors
research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men
research Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibitor, in men with male pattern hair loss☆, ☆☆, ★, ★★
research The Long-Term Effect Of Specific Type II 5??-Reductase Inhibition With Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo Controlled Trial
research Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5α-Reductase Inhibitors
research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors
research Estudo do estroma reativo prostático após a orquiectomia bilateral e posterior inibição da atividade da aromatase pela crisina e inibição da atividade da 5-alfa-redutase pela finasterida
research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAAReceptor Function and Seizure Susceptibility
Stress increases neurosteroids that help prevent seizures.
research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin
Sebocytes play a key role in controlling androgen levels in human skin.
research Androgens and alopecia
Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.
research Understanding the Epidemiology, Natural History, and Key Pathways Involved in Prostate Cancer
Prostate cancer was a major health issue in 2009, especially for Black men, and targeting the 5alpha-reductase enzyme could help in its prevention and treatment.
research Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol
Testosterone increases seizure risk through its conversion to specific neurosteroids.
research Changes in Expression and Function of Extrasynaptic GABAAReceptors in the Rat Hippocampus during Pregnancy and after Delivery
Pregnancy increases certain GABAA receptors in rat brains, influenced by steroid levels.
research Diagnosis of hyperandrogenism: Biochemical criteria
The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.
research Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.
research Potential targets in the discovery of new hair growth promoters for androgenic alopecia
The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
research Clinical biochemistry of dihydrotestosterone
Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
research Skin steroidogenesis in health and disease
The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.
research Mechanism of action of herbs and their active constituents used in hair loss treatment
Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.
research 5α-Reduced glucocorticoids: a story of natural selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
research Influence of estrogens on the androgen metabolism in different subunits of human hair follicles.
Estrogens can reduce DHT production in hair follicles, but are less effective than finasteride and progesterone.
research Finasteride
Finasteride treats enlarged prostate, improves urinary flow, but may cause sexual side effects.
research Hair loss and herbs for treatment
Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.
research Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line
Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
research Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.
research Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
Progesterone's anesthetic effects don't rely on progesterone receptors.
research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach
Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
research Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration
Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.