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Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.

research The effects of melatonin treatment on wool production and hair follicle cycle in angora rabbits

7 citations , January 2001 in “Annales de zootechnie”

Melatonin treatment increases wool production and improves fiber quality in angora rabbits.

A Randomized Double-Blind Placebo-Controlled Clinical Trial to Evaluate the Effect of an Annurca Apple Supplement Formula in Androgenic Alopecia

research A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia

May 2023 in “Journal of Applied Cosmetology”

The Annurca apple supplement significantly improved hair growth in people with hair loss.

research Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices

43 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Progesterone protects neurons from damage by converting to allopregnanolone, which works through GABAA receptors.

research Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling

12 citations , March 2018 in “Analytical chemistry”

Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.

research Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

7 citations , March 2013 in “Tetrahedron Letters”

New method makes important drug ingredients more easily without needing extra purification steps.

research Testosterone replacement in the setting of Finasteride therapy: a therapeutic dilemma

1 citations , January 2010 in “Endocrine abstracts”

research Androgens

January 2007 in “xPharm: The Comprehensive Pharmacology Reference”

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

A 5α-Reductase Inhibitor, Finasteride, Increases Differentiation and Proliferation of Embryonal Carcinoma Cell-Derived Neural Cells

research A 5α-reductase inhibitor, finasteride, increases differentiation and proliferation of embryonal carcinoma cell-derived-neural cells

4 citations , September 2010 in “Medical Hypotheses”

research Alfuzosin/finasteride

May 2023 in “Reactions Weekly”

research Alfuzosin/finasteride

January 2013 in “Reactions Weekly”

Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

research Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

12 citations , March 1995 in “Journal of the American Chemical Society”

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

research Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation

12 citations , June 2019 in “Psychoneuroendocrinology”

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

research Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil

1 citations , October 2017 in “Food Additives & Contaminants: Part A”

A new minoxidil-like substance, triaminodil, was found in an illegal hair growth supplement.

research Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5.ALPHA.-Reductase Inhibitor

21 citations , January 2010 in “JOURNAL OF HEALTH SCIENCE”

Abietic acid from pine resin can effectively inhibit testosterone 5α-reductase.

research Attenuating 5α-pregnane-3α-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures

21 citations , February 2005 in “Epilepsy & Behavior”

Reducing 3α,5α-THP in the hippocampus increases seizures in female rats.

research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

9 citations , March 2018 in “International journal of molecular sciences”

Allopregnanolone changes gene expression in glioblastoma cells.

research Pharmacodynamics and pharmacokinetics of P-3074, a new finasteride topical solution, administered at four different doses

January 2014

P-3074 effectively blocks scalp DHT better than oral finasteride.

research Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output

52 citations , April 2002 in “Brain Research”

Lower allopregnanolone levels increase stress-related dopamine release in the brain.

research Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist

5 citations , December 2011 in “Drug Research”

CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

research Dutasteride Improves Nocturia but Does Not Lead to Better Sleep: Results from the REDUCE Clinical Trial

3 citations , February 2021 in “The Journal of Urology”

Dutasteride can reduce night-time urination but it doesn't improve sleep quality.

research Effects of Transcutol P and Precirol ATO-5 on Percutaneous Absorption of Flutamide from Emulgels

June 2021 in “Pharmaceutical sciences”

Flutamide emulgel with 1% Transcutol P absorbs better through the skin than other mixtures.

research The Opiate Antagonist, Naltrexone, in the Treatment of Trichotillomania

69 citations , October 2013 in “Journal of Clinical Psychopharmacology”

Naltrexone did not significantly reduce hair pulling but improved cognitive flexibility.

research Epitestosterone—an endogenous antiandrogen?

35 citations , November 1989 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

Epitestosterone may act as a weak antiandrogen and can inhibit an enzyme involved in testosterone metabolism.

research Finasteride affects the testicular physiology of gilthead seabream males

January 2016 in “ISBN: 978-84-608-9184-0”

research Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

2 citations , March 2022 in “Laboratory Animal Research”

A mild botulinum toxin injection improved sperm production and movement in aging mice.

Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

research Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

36 citations , October 2009 in “Journal of Investigative Dermatology”

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

research 5α‐reductase inhibitors: Evaluation of their potential confounding effect on GC‐C‐IRMS doping analysis

3 citations , July 2021 in “Drug Testing and Analysis”

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

research 5 alpha-reductase inhibition by a new synthetic steroid (PM-9) in cultures of Penicillium crustosum.

1 citations , January 2002 in “PubMed”

PM-9, like finasteride, may help treat certain diseases by blocking a key enzyme.

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