February 2026 in “ImmunoTargets and Therapy” Tumor immunotherapy can cause hair loss by disrupting hair follicle immunity.
January 2026 in “Dermatology and Therapy” Poor sleep may lead to hair loss, and hair loss may affect sleep.
September 2025 in “Romanian Journal of Medical Practice” Iron deficiency is linked to female pattern hair loss.
23 citations
,
June 2012 in “PLOS ONE” KLF4 is important for maintaining skin stem cells and helps heal wounds.
242 citations
,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
95 citations
,
July 2010 in “Genes & development” Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
34 citations
,
June 2008 in “In vitro cellular & developmental biology. Animal” Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
24 citations
,
October 2017 in “Biomolecules” Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.
24 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” Hair restoration surgery can have complications; success depends on patient education, careful planning, and proper execution.
19 citations
,
April 2015 in “Stem Cells” Pro-IGF-II improves muscle repair in old mice.
16 citations
,
August 2022 in “Nature Communications” ROR2 is essential for hair follicle stem cell renewal and maintenance.
16 citations
,
March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
7 citations
,
May 2019 in “Journal of the Formosan Medical Association” HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.
1 citations
,
January 2014 in “Elsevier eBooks” Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.
March 2026 in “Frontiers in Medicine” Different types of alopecia cause hair loss due to immune system issues, with some allowing regrowth and others causing permanent loss.
February 2025 in “Cureus” Hair transplants can rarely cause scalp inflammation leading to hair loss, needing early detection and treatment.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.
January 2023 in “Book of Abstracts” COVID-19 can cause different types of hair loss, with telogen effluvium being the most common.
74 citations
,
June 2018 in “Cell death and disease” Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.
173 citations
,
May 2001 in “Human reproduction update” Oestrogens are key for bone growth during puberty in both boys and girls.
30 citations
,
December 2011 in “Journal of biological chemistry/The Journal of biological chemistry” Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.
2 citations
,
August 2022 in “Emergency medicine international” Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.
43 citations
,
September 2014 in “Molecular Plant” CLE40 and CRN/CLV2 pathways have opposite effects on root growth in Arabidopsis.
25 citations
,
August 2007 in “Molecular Therapy” Researchers found a safe and effective way to pick genetically modified skin cells with high growth potential using CD24.
25 citations
,
June 2012 in “Endocrine” PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.
1 citations
,
September 2023 in “Clinical, cosmetic and investigational dermatology” Certain genetic variants linked to immune response increase the risk of alopecia areata in Taiwanese people.
August 2010 in “Journal of Investigative Dermatology” New hair regrowth model introduced, imiquimod kills skin cancer cells, T-cadherin loss makes skin cancer more invasive, no strong link between PTCH1 gene and skin cancer after transplant, and male teens more likely to have hereditary hair loss.
January 2013 in “Dermatologic Clinics” Hair disorders need a holistic approach, including medical, cosmetic, and psychological support.
3 citations
,
September 2019 in “Journal of Orthodontics” A boy's hair grew back after he stopped using orthodontic headgear that caused temporary hair loss.
254 citations
,
January 2012 in “Nature Reviews Molecular Cell Biology” Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.