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Preclinical Evidence Supporting Selective Inhibition of Tyrosine Kinase 2-Dependent, IL-12-Mediated Signaling as a Novel Strategy for Alopecia Areata Management

research 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking TYK2 might be a new way to treat hair loss from alopecia areata.

research Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

research Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

25 citations , December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Targeted cytokine treatments may help with alopecia areata, but more research is needed.

research Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis

208 citations , November 2000 in “Development”

Edar and Eda proteins are crucial for proper tooth development.

research RAPID ALKALINIZATION FACTOR 22 is a key modulator of the root hair growth responses to fungal ethylene emissions in Arabidopsis

7 citations , September 2024 in “PLANT PHYSIOLOGY”

RALF22 is essential for root hair growth in response to fungal emissions in Arabidopsis.

research Stimulation of ectodermal organ development by Ectodysplasin-A1

249 citations , May 2003 in “Developmental Biology”

Ectodysplasin-A1 is crucial for developing hair, teeth, and glands.

research Pre-keratin isolated from epidermal microsomes

7 citations , December 1970 in “Biochimica et Biophysica Acta (BBA) - Protein Structure”

Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus Aureus-Infected Wounds in Normal and Diabetic Mice

research 1431 Neutralizing α-toxin accelerates healing of Staphylococcus aureus-infected wounds in normal and diabetic mice

April 2018 in “Journal of Investigative Dermatology”

Blocking α-toxin helps heal Staphylococcus aureus-infected wounds faster in both normal and diabetic mice, with different effects on their immune responses.

The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

research The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

research Ultrastructural visualization of cross-linked protein features in epidermal appendages

43 citations , July 1994 in “Journal of Cell Science”

Cross-linked proteins help maintain the structure of hair, feathers, and hagfish teeth.

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