research Expression of retinoid-X receptors (-Æ,-a,-a) and retinoic acid receptors (-Æ,-a,-a) in normal human skin: an immunohistological evaluation
RXR and RAR proteins in skin may help with cell growth, hair growth, and gland function.
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750-780 / 1000+ resultsresearch Limosilactobacillus fermentum MF10 promotes hair growth through upregulation of Wnt/β-catenin signaling in C57BL/6 mice
Limosilactobacillus fermentum MF10 helps hair grow by activating certain cell signals in mice.
research Frequency of dermatophytes and yeasts on tegument of healthy dogs and cats
Healthy dogs and cats often carry skin fungi without showing symptoms, which can spread to others.
research Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors
The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.
research Glycogen phase separation drives macromolecular rearrangement and asymmetric division in E. coli
Glycogen helps E. coli cells divide unevenly and organize their contents.
research Tofacitinib for the treatment of alopecia areata in preadolescent children
Tofacitinib helped some young children with severe hair loss grow their hair back without bad side effects.
research The Janus kinase 1 inhibitor abrocitinib for the treatment of oral lichen planus
research Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design
Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.
research Study on applicability of microbial test method of hair cosmetics
Current microbial test methods for hair cosmetics need revision due to strong bacteriostasis.
research CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico
CTLA4 gene variants are not linked to alopecia areata in Monterrey's Mexican population.
research Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double‐blind, placebo‐controlled trial
The ALLEGRO phase 2b/3 trial evaluated the efficacy and safety of ritlecitinib, a JAK3/TEC family kinase inhibitor, in 105 adolescents aged 12-17 with alopecia areata and ≥50% scalp hair loss. Over 48 weeks, 25%-50% of patients in the ritlecitinib groups achieved significant hair regrowth (SALT score ≤20), compared to 0% in the placebo group. Additionally, 44%-80% of adolescents reported moderate to great improvement in their condition with ritlecitinib, versus 10%-22% with placebo. Common adverse events included headache, acne, and nasopharyngitis, but no severe adverse events were reported. Overall, ritlecitinib showed promising efficacy and a favorable safety profile for treating alopecia areata in adolescents.
research Androgen Receptor Blockade Induces the Phagocytosis of MRSA and Pseudomonas aeruginosa by Monocyte-Derived Macrophages In Vitro
Blocking androgen receptors boosts macrophages' ability to clear certain bacteria.
research Acitretin Loaded Nanocarrier Gel: Formulation and Exploration of In-vitro Release Kinetics
The new gel formulation for Acitretin improves topical delivery and reduces oral toxicity.
research JAK Inhibitor Therapy in Alopecia Areata with Latent Hepatitis B Virus or Tuberculosis Infection: A Safety Assessment
JAK inhibitors can be safely used for alopecia areata in patients with latent hepatitis B or stable tuberculosis with proper monitoring.
research Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity
Plasmalogens activate a channel in cells that may stimulate hair growth.
research Supplemental Material: Tolerability and Efficacy of Unorthodox Dosing Regimens of Tofacitinib and Baricitinib in Pediatric Patients with Moderate to Severe Alopecia Areata
Standard dosing is more effective for severe alopecia areata in children, but unorthodox dosing can be safe and considered if needed.
research Androgens inhibit phagocytosis by macrophages via the androgen receptor in vitro
Male hormones can decrease the ability of immune cells to fight bacteria.
research Oral isotretinoin as the most effective treatment in folliculitis decalvans: a retrospective comparison of different treatment regimens in 28 patients
Oral isotretinoin is the most effective treatment for folliculitis decalvans.
research Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study
Five preservatives may disrupt hormone function and need more health and environmental risk assessment.
research Acromegaloid Facial Appearance: Case Report and Literature Review
The document concludes that AFA should be considered in patients with acromegaly-like features but normal hormone levels, and more cases need to be identified to understand the condition fully.
research 1048 Treatment of nodulocystic acne with once weekly finasteride: A pilot study
research Efficacy of tofacitinib as an induction agent in severe alopecia areata compared to oral betamethasone weekly pulse
Tofacitinib is effective for severe alopecia areata, similar to oral betamethasone.
research Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis
Inflammation damages sweat ducts, causing sweat gland injury.
research Frequency of dermatophytes and yeasts on tegument of healthy dogs and cats
Healthy dogs and cats can carry and spread skin infections without showing symptoms.
research The analysis of scalp irritation by coacervates produced in hair shampoo via FTIR with focal plane array detector, X‐ray photoelectron microscopy and HaCaT cells
Shampoo coacervates can cause scalp irritation due to released surfactants.
research Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17
Androgens like testosterone increase colon muscle contractions by affecting calcium pathways.
research Hypotrichosis in a child with olmsted syndrome
A child with Olmsted syndrome showed mild improvement in hair and skin issues with treatment.
research A Promising Efficacy of Tofacitinib in an Adult Patient with Alopecia Areata
Tofacitinib effectively treated severe hair loss in a patient who didn't respond to other treatments.
research Catagen in the hairless house mouse
Hairless mice have longer hair follicles and abnormal structures during the catagen phase.
research Fucoidan-derived carbon dots against Enterococcus faecalis biofilm and infected dentinal tubules for the treatment of persistent endodontic infections
Fucoidan-derived carbon dots can effectively treat root canal infections by killing bacteria and are safer than traditional disinfectants.