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GlossaryActivin

protein regulating cell growth and hair follicle development

Activin is a protein that plays a crucial role in regulating various biological processes, including cell growth, inflammation, and hormone secretion. It is particularly important in the context of hair biology, as it can influence hair follicle development and cycling, potentially impacting conditions like alopecia.

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Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

research Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

204 citations , October 1999 in “EMBO journal”

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

research Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

163 citations , October 2001 in “EMBO journal”

Overexpressing follistatin in mice delays wound healing and reduces scar size.

research Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair

113 citations , December 2000 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

KGF and activin are crucial for skin healing and repair.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

research Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin

81 citations , January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

research The roles of activins in repair processes of the skin and the brain

52 citations , July 2001 in “Molecular and cellular endocrinology”

Activin A helps heal skin wounds and protects the brain after injury.

research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

46 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

The Activin Binding Proteins Follistatin and Follistatin-Related Protein Are Differentially Regulated In Vitro and During Cutaneous Wound Repair

research The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair

46 citations , December 2001 in “Journal of Endocrinology/Journal of endocrinology”

FLRG and follistatin have different roles in wound healing.

research The role of activins and follistatins in skin and hair follicle development and function

45 citations , October 2008 in “Cytokine & Growth Factor Reviews”

Activins and follistatins, part of the TGFβ family, are crucial for hair follicle development and skin health, affecting growth, repair, and the hair cycle.

research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK—ERK Signaling Pathway

45 citations , April 2013 in “Cell Transplantation”

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

39 citations , March 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

GLI2 increases follistatin production in human skin cells.

research Activin B Promotes Epithelial Wound Healing In Vivo through RhoA-JNK Signaling Pathway

38 citations , September 2011 in “PLOS ONE”

Activin B helps heal skin wounds and grow hair by activating a specific cell signaling pathway.

research Regulatory T cells are required for normal and activin‐promoted wound repair in mice

29 citations , February 2018 in “European Journal of Immunology”

Regulatory T cells are essential for normal and improved wound healing in mice.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

research A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

15 citations , June 2019 in “eLife”

Activin A and follistatin control when hair cells develop in mouse ears.

Activin A-Induced Signaling Controls Hair Follicle Neogenesis

research Activin A-induced signalling controls hair follicle neogenesis

5 citations , October 2016 in “Experimental Dermatology”

Activin A is important for creating new hair follicles.

research Activin B Promotes Initiation and Development of Hair Follicles in Mice

5 citations , January 2013 in “Cells Tissues Organs”

Activin B helps start and grow hair follicles in mice.

research Author response: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

May 2019

Activin A and follistatin control when ear hair cells form in mice.

research Decision letter: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

May 2019

Activin A promotes ear hair cell development, while follistatin delays it.

research Faculty Opinions recommendation of A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea.

July 2019 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Activin A speeds up ear hair cell differentiation, while Follistatin slows it down.

research Supplementary Material for: Activin B Promotes Initiation and Development of Hair Follicles in Mice

January 2013

Activin B helps start and grow hair follicles in mice.

research Activin A and Follistatin influence hair follicle development in mice

January 2007

Activin A and Follistatin affect how mouse hair follicles grow.

research Rupert Raj’s Written Acts of Activism and Care Throughout the 1980s and 1990s

January 2025 in “Amplify A Journal of Writing-as-Activism”

Rupert Raj supported trans individuals by sharing vital information and resources, boosting their confidence and security.

research Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

111 citations , June 2002 in “The EMBO Journal”

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research The Role of Smads in Skin Development

59 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

research Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

43 citations , February 2013 in “Developmental dynamics”

Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.

research Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

37 citations , January 2022 in “Frontiers in Genetics”

Aging reduces dermal sheath cells, affecting youthful skin appearance.

research Endocrine Functions of the Testes

3 citations , November 2021 in “IntechOpen eBooks”

The testes produce important hormones like testosterone and others that play key roles in male body functions.

research Impact of One-Week Administration of Dihydrotestosterone in Rat Anterior Pituitary Gland

1 citations , October 2022 in “International journal of endocrinology”

Dihydrotestosterone changes some hormone-related gene expressions in rat pituitary glands but doesn't affect the estrous cycle.