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Upadacitinib effectively treats severe alopecia areata and is safe.

Higher FABP4 levels may help diagnose androgenetic alopecia early.

Altering SSAT affects fat metabolism and body fat in mice.

Acne patients have higher levels of mTOR in their skin, which could be linked to future metabolic disease.

The research identified unique metabolic activities in immune cells associated with hair loss in Alopecia Areata.

Testosterone reduces knee movement, while flutamide and finasteride increase it.

Upadacitinib may effectively treat resistant lichen planopilaris.

PPARs help regulate skin health and could be used to treat skin disorders.

Janus kinase inhibitors reduce inflammation markers in severe alopecia areata patients.

Upadacitinib helped regrow hair in a severe alopecia areata patient but stopping treatment caused hair loss to return.

Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.

β‐thymosins, especially thymosin β4, help in heart protection, wound healing, and hair growth by stabilizing actin in cells.

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

KATP channel openers may cause peripheral edema by reducing lymphatic contractions and flow.

Phospholipase A2 enzymes play key roles in skin health and disease.

Skin problems like excessive hair growth, acne, and dark skin patches can be signs of Polycystic Ovarian Disease, which may also be linked to family history and a risk for diabetes.

Low oxygen levels affect the behavior of certain proteins in human skin cells.

Jawless vertebrates have teeth proteins similar to those in mammalian hair and nails.

JAK-inhibitors for alopecia areata are generally safe with mostly mild side effects and a low rate of treatment withdrawal.

Mutations in hKAP1 genes may cause hereditary hair disorders.

JAK inhibitors might help treat alopecia areata.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

PD‐L1 and PD‐L2 may not effectively control immune activation in alopecia areata.

CCN1 may aid wound healing, but more research with larger samples is needed.

Children with metabolic syndrome often have skin problems like dark patches, skin tags, stretch marks, infections, acne, and psoriasis, which are linked to obesity and insulin resistance.

Korean patients with PCOS often have skin problems like acne and excess hair, with different symptoms based on their specific PCOS type.

Exposure to fatty acids significantly increased androgen levels in female dogs, suggesting a link to conditions like insulin resistance and PCOS.

Certain proteins are significantly increased in the skin of people with hidradenitis suppurativa.