research New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics
New drugs and therapies targeting specific pathways show promise in treating advanced prostate cancer.
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research Treatment of androgenic disorders with dexamethasone: Dose-response relationship for suppression of dehydroepiandrosterone sulfate
Lower doses of dexamethasone can safely reduce high DHEAS levels in women with androgenic disorders.
research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells
Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.
research Influence of age and of testosterone on the response of male rats to parachlorophenylalanine
PCPA induces hypersexual behavior in male rats regardless of age or castration status.
research Kutane Androgenisierung - Effluvium, Hirsutismus, Akne
Androgens can cause acne, excess hair, and hair loss, treatable with dermatologist-guided therapies.
research Development of an aequorin-based assay for the screening of corticotropin-releasing factor receptor antagonists
The new assay can help develop products for hair re-growth.
research Dihydrotestosterone—a culprit in left ventricular hypertrophy
Dihydrotestosterone (DHT) worsens heart enlargement, and blocking it may help prevent heart issues.
research Reversal of andro-genetic alopecia in a male. A spironolactone effect?
A man's baldness improved possibly due to a medication that blocks male hormones.
research DIAGNOSTIC AND THERAPEUTIC UTILITY OF GONADOTROPHIN-RELEASING HORMONE AGONIST IN POSTMENOPAUSAL HYPERANDROGENISM OF OVARIAN ORIGIN
GnRH agonist effectively diagnoses and treats postmenopausal hyperandrogenism from ovarian sources.
research Acute urinary retention: risks and management.
Older men with severe symptoms and larger prostates should focus on prevention, using finasteride and alpha-blockers to manage acute urinary retention.
research Protective effects of finasteride against testosterone-induced calcium oxalate crystallization and crystal-cell adhesion
Finasteride helps prevent kidney stones, but side effects need more research.
research Selective androgen receptor modulators: a critical appraisal
SARMs show promise but need more evidence to prove they're better than traditional androgens.
research The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation
The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.
research Clascoterone as a novel treatment for androgenetic alopecia
Clascoterone may be a promising treatment for hair loss.
research Androgen receptors are only present in mesenchyme-derived dermal papilla cells of red deer (Cervus elaphus) neck follicles when raised androgens induce a mane in the breeding season
Red deer only have androgen receptors in neck hair cells for mane growth during breeding season.
research A0366 Comparative effects of finasteride and dutasteride on semen parameters in young men with androgenic alopecia: A randomized controlled study
research Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models
Stress worsens Tourette symptoms by increasing allopregnanolone levels.
research Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women
The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.
research FINASTERIDE AND PSA
research Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer
Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.
research Androgens in Women – Critical Evaluation of the Methods for Their Determination in Diagnostics of Endocrine Disorders
The conclusion is that standardizing testosterone measurement methods is essential for better diagnosis accuracy in women.
research A Preliminary Assessment of Steroid Reproductive Hormones in Archaeological Human Hair Utilizing a Modified Enzyme-Linked Immunosorbent Assay (ELISA) Technique
Steroid hormones can be preserved in ancient hair, revealing insights into past health and fertility.
research Association of 5-α reductase inhibitors and sexual dysfunction: A RADAR report
Using hair loss drugs finasteride and dutasteride may cause sexual side effects.
research The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-androgen “Cyproterone Acetate” for Therapy
Cyproterone acetate combined with ethinyl estradiol significantly reduced hirsutism in women.
research Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals
5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.
research Adverse Effects of 5-Alpha-Reductase Inhibitors: a narrative review
5-Alpha-Reductase Inhibitors can cause negative side effects.
research The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific
Dutasteride and finasteride affect different cell types differently.
research Mechanism of action of androgen in hair follicles
Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.
research Oral Testosterone With and Without Concomitant Inhibition of 5α-Reductase by Dutasteride in Hypogonadal Men for 28 Days
Taking oral testosterone with or without dutasteride increases testosterone levels and could be an effective treatment for low testosterone.
research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.