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Hair and Nail Adverse Events During Treatment with Targeted Therapies for Metastatic Melanoma

research Hair and nail adverse events during treatment with target therapies for metastatic melanoma

April 2016 in “Journal of The American Academy of Dermatology”

People with certain allergic conditions or higher white blood cell counts have more severe hair loss, and treating hair and nail side effects early in melanoma therapy can improve quality of life.

research Reporting on Adverse Clinical Events

November 2015 in “Clin-Alert”

Some medications and supplements can cause serious side effects, including hair loss, heart rhythm problems, liver injury, and other health issues.

research Reporting on Adverse Clinical Events

November 2010 in “Clin-Alert”

Monitoring for adverse effects in clinical treatments is crucial.

research Reporting on Adverse Clinical Events

October 2008 in “Clin-alert”

Certain medications can reduce mortality risk in COPD patients, but others can increase risks of cardiovascular issues, postoperative delirium, and other adverse effects.

research Finasteride: suicidality or psychological adverse events

November 2020 in “Reactions Weekly”

Finasteride use linked to increased suicidality in patients under 45.

Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis

research Faculty Opinions recommendation of Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis.

April 2015 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The safety of the hair loss drug finasteride is unclear due to inadequate reporting in clinical trials.

research A rare adverse event following laser hair reduction

April 2024 in “International Journal of Women’s Dermatology”

Laser hair reduction can sometimes cause a rare skin condition called Fox-Fordyce disease.

research Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

68 citations , January 2014 in “Dermatology research and practice”

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

research Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

40 citations , November 2020 in “JAMA Dermatology”

Finasteride may cause suicidal thoughts and mental side effects, especially in young people with hair loss.

research The management of EGFR inhibitor adverse events: a case series and treatment paradigm

32 citations , January 2012 in “International Journal of Dermatology”

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

research FDA Reports of Alopecia as an Adverse Event to Isotretinoin

5 citations , July 2019 in “Journal of Cutaneous Medicine and Surgery”

Isotretinoin may cause hair loss, especially in women and young adults.

research Clinical perspective on management of key adverse events with sacituzumab govitecan

1 citations , September 2025 in “The Oncologist”

Effective management of side effects is crucial for safe use of sacituzumab govitecan in advanced breast cancer treatment.

Signal Mining for Non-Bleeding Adverse Events in Novel Oral Anticoagulants: A Pharmacovigilance Study Based on the FAERS Database

research Signal Mining for Non-Bleeding Adverse Event in Novel Oral Anticoagulants: A Pharmacovigilance Study Based on the FAERS Database

July 2025

Different oral anticoagulants cause various non-bleeding side effects, so careful monitoring is needed.

Safety Concerns of Paternal Drug Exposure on Fertility, Pregnancy, and Offspring: An Analysis Based on the FDA Adverse Event Reporting System

research Safety concerns of paternal drug exposure on fertility, pregnancy and offspring: An analysis based on the FDA adverse event reporting system

October 2024 in “Andrology”

Paternal drug exposure can harm fertility, pregnancy outcomes, and offspring health, with specific drugs linked to various reproductive issues.

Low-Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System With a Focus on Pericardial Effusions

research Low‐Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System (FAERS) With a Focus on Pericardial Effusions

September 2024 in “Journal of Cosmetic Dermatology”

Low-dose oral minoxidil can cause serious side effects like heart issues, so use the lowest effective dose.

Comments Concerning the Real Risk of Sexual Adverse Events Secondary to the Use of 5-Alpha-Reductase Inhibitors

research Comments concerning the real risk of sexual adverse events secondary to the use of 5-ARIs

January 2016 in “Archivio italiano di urologia, andrologia”

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

research Alopecia areata as an immune-related adverse event associated with response to immune checkpoint inhibitors

3 citations , July 2022 in “European Journal of Dermatology”

Brodalumab is more effective than ustekinumab for treating psoriasis.

research Are finasteride-related penile curvature/Peyronie’s disease Adverse Event Reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases

2 citations , May 2022 in “International Journal of Impotence Research”

Finasteride may be linked to Peyronie’s disease, but more research is needed.

research Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database

1 citations , May 2021 in “Scientific Reports”

Certain cancer drugs are strongly linked to nerve damage, requiring close monitoring and early treatment.

research Anti-EGFR mechanism of action: antitumor effect and underlying cause of adverse events.

91 citations , April 2006 in “PubMed”

EGFR-targeting cancer drugs can cause skin rashes and other side effects.

research Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

41 citations , December 2019 in “Science Translational Medicine”

Anti-EGFR therapy can cause skin issues, but FGF7 treatment might help.

Neutralization of IL-8 Prevents Dermatologic Adverse Events Associated with Epidermal Growth Factor Receptor Inhibition

research Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor

32 citations , June 2012 in “PLoS ONE”

Blocking IL-8 can reduce skin rashes from cancer treatment.

research Safety profile of human papilloma virus vaccines: an analysis of the US Vaccine Adverse Event Reporting System from 2007 to 2017

22 citations , December 2018 in “British Journal of Clinical Pharmacology”

HPV vaccines are generally safe but need further investigation for rare side effects.

research Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events

21 citations , December 2022 in “Pharmaceutics”

Laser-assisted drug delivery is generally safe with mostly mild side effects.

research “Nail loss after teriflunomide treatment: A new potential adverse event”

6 citations , September 2017 in “Multiple Sclerosis and Related Disorders”

Nail loss may be a side effect of the MS drug teriflunomide.

Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force Dermatology for Cancer Patients International Study

research Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study

1 citations , July 2023 in “Cancers”

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

The Role of Patient and Drug-Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System

research The Role of Patient‐ and Drug‐Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System

December 2024 in “Journal of Cosmetic Dermatology”

Oral minoxidil rarely causes pericardial effusion, especially at low doses.

research Drug-Induced Hair Loss: Analysis of the Food and Drug Administration’s Adverse Events Reporting System Database

July 2024 in “Skin Appendage Disorders”

Certain medications, including some immune drugs, contraceptives, and hair loss treatments, are often linked to hair loss.

A Pharmacovigilance Study of Drug-Reduced Male Semen Quality Based on the Food and Drug Administration Adverse Event Reporting System Database

research A pharmacovigilance study of drug‐reduced male semen quality based on the Food and Drug Administration adverse event reporting system database

June 2024 in “Andrology”

Some drugs can reduce male semen quality.

Medication Clusters at Hospital Discharge and Risk of Adverse Drug Events at 30-Days Post-Discharge: A Population-Based Cohort Study of Older Adults

research Medication Clusters at Hospital Discharge and Risk of Adverse Drug Events at 30-days Post-Discharge: A Population-based Cohort Study of Older Adults

August 2022 in “medRxiv (Cold Spring Harbor Laboratory)”

Certain groups of medications given when leaving the hospital are linked to a higher risk of negative drug reactions within 30 days, especially in older adults with respiratory issues.

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