MFN2 mutations cause mitochondrial problems, leading to more upper body fat and lower leptin levels.
April 2023 in “Journal of Investigative Dermatology” Mast cells and the CB1 receptor may be key in causing IgA vasculitis.
7 citations
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January 2023 in “Frontiers in Cell and Developmental Biology” Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.
April 2017 in “Journal of Investigative Dermatology” Cow milk sugars increase fat production and inflammation in skin oil cells.
May 2026 in “Journal of Controlled Release” December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Actin filaments help stabilize and integrate cell membranes during transfer.
December 2020 in “Innovation in aging” Rapamycin treatment helps reduce brain inflammation and symptoms of mitochondrial disease by blocking specific pathways in mice.
January 2023 in “Toxicological Research”
January 2025 in “PLoS ONE” Aligned membranes improve wound healing by reducing scars and promoting skin regeneration.
January 2019 in “Springer eBooks” Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.
32 citations
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October 2004 in “Experimental Dermatology” α-MSH may help treat skin inflammation and fibrosis.
July 2024 in “Journal of Investigative Dermatology” Mechanical tension worsens keloid scars by activating inflammation and fibrosis pathways.
52 citations
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August 2021 in “Microorganisms” Higher ACE2 levels in certain tissues may worsen COVID-19 in people with other health issues, especially older adults.
5 citations
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November 2005 in “Journal of Investigative Dermatology” July 2024 in “Journal of Investigative Dermatology”
15 citations
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November 2023 in “Immunity & ageing” TLR4 is important in aging-related diseases and could be a new treatment target.
1 citations
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February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” A peptide from hair follicle stem cells promotes hair growth by activating specific skin cells.
April 2010 in “Cancer Research” Mcl-1 can activate Wnt signaling in skin cells, promoting growth and possibly cancer.
May 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Calprotectin starves Pseudomonas aeruginosa of essential metals, affecting its growth and resistance.
Hit15 shows promise as a COVID-19 treatment by reducing virus infection and inflammation.
April 2025 in “International Journal of General Medicine” The G allele of IFITM3 rs12252 is linked to more severe COVID-19.
42 citations
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February 2019 in “Circulation” Targeting ATM could help manage heart cell enlargement due to pressure overload.
6 citations
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October 2024 in “International Journal of Dermatology” Proinflammatory fibroblasts and vascular endothelial cells are key in keloid development.
Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.
47 citations
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June 2012 in “Genes & Development” A mother's western diet can make her milk toxic, causing inflammation and hair loss in babies.
89 citations
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March 1996 in “Proceedings of the National Academy of Sciences” CD18-deficient mice developed psoriasis-like skin disease, useful for studying inflammatory skin disorders.
July 2022 in “Journal of Investigative Dermatology” Inhibiting TYK2 can restore hair growth in alopecia areata.
March 2024 in “Frontiers in endocrinology” A new MTX2 gene mutation caused a severe genetic disorder in a young Chinese girl.
April 2023 in “Journal of Investigative Dermatology” RNase L suppresses regeneration in mammals.
22 citations
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June 2010 in “Experimental Dermatology” Lower MC2R expression may contribute to alopecia areata.