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Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

Some prostate cancers have gene changes that may affect treatment with certain drugs.

Researchers found a new mutation in the EDA gene that likely causes missing teeth and mild skin symptoms in one family.

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

A new genetic disorder caused by an ODC1 mutation can be treated with DFMO.

Four-amino acid part makes enzyme sensitive to finasteride.

OR2AT4 helps reduce aging and cell damage in human skin cells.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.

A mutation in the Soat1 gene causes hair structure defects and other health issues in AKR/J mice.

KRTAP2 genes are crucial for hair structure and may impact hair disorders and treatments.

Most genetic mutations causing hypohidrotic ectodermal dysplasia in Russian patients are found in the EDA gene.

KRT14 gene variants cause dermatopathia pigmentosa reticularis, affecting nails, teeth, and hair.

A new mutation in the XEDAR gene might cause a rare skin condition called hypohidrotic ectodermal dysplasia.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

The enzyme Dgat1 is essential for healthy hair and skin by controlling retinoid levels.

A KRT32 gene variant causes loose anagen hair syndrome.

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

Introducing the rat OTC gene partially corrected OTC deficiency in mice.

Gene differences may affect baldness treatment response in Korean men.

Gene variation affects prostate issues and hair loss.

A rabbit gene important for hair development was identified and detailed.

Double-stranded RNA activates a pathway that causes a skin protein to be expressed in the wrong place.