October 2024 in “Archives of Dermatological Research” Higher GPER-1 levels are linked to more severe and shorter-duration androgenetic alopecia, suggesting GPER-1 as a potential treatment target.
35 citations
,
April 2013 in “Sexual medicine reviews” 5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
4 citations
,
May 2021 in “Biomedicines” Targeting the protein Caveolin-1 might help treat a type of scarring hair loss called Frontal Fibrosing Alopecia.
6 citations
,
April 2022 in “Frontiers in cell and developmental biology” The research identified key proteins and genes that may influence wool bending in goats.
52 citations
,
February 2006 in “Current pharmaceutical design” 5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.
51 citations
,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
28 citations
,
January 2013 in “Stem cells” Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.
20 citations
,
December 2013 in “Journal of Dermatology” UV-B light increases inflammation-related substances in acne-related skin cells.
17 citations
,
July 2018 in “International Journal of Cosmetic Science” Keratin-based particles safely improve hair strength, smoothness, and heat protection.
6 citations
,
May 2013 in “PloS one” The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.
60 citations
,
July 2011 in “Stem Cells and Development” Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
3 citations
,
January 2011 in “Annals of Dermatology” Blocking EGFR in skin cells doesn't majorly increase inflammation markers.
107 citations
,
December 2013 in “International Journal of Dermatology” The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.
25 citations
,
August 2015 in “International Journal of Cosmetic Science” Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.
24 citations
,
September 2005 in “Journal of Cellular Biochemistry” Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.
2 citations
,
February 2023 in “BMC women's health” Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.
Enhanced stem cells from the placenta can reduce fat cell formation in eye disease.
8 citations
,
April 2009 in “International journal of oncology” Hair follicle cells resist turning into skin cells.
18 citations
,
January 2008 in “Journal of The American Academy of Dermatology” Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.
10 citations
,
January 2014 in “Journal of prosthodontic research” Bioengineered salivary glands in mice can produce saliva when tasting sour or bitter, but have different protein levels and nerve signals compared to natural glands.
6 citations
,
September 2012 in “Clinical Interventions in Aging” Honokiol might help reduce male skin aging by maintaining testosterone levels.
September 2024 in “Chemico-Biological Interactions” Finasteride improves heart function in obese and aging male rats by reducing oxidative stress and p53 protein levels.
April 2026 in “Frontiers in Cell and Developmental Biology” GPCRs are vital for wound healing by affecting cell growth and immune response.
January 2006 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” Rubus coreanum may help hair growth but not through the tested mechanisms, and none of the herbal extracts help with acne.
169 citations
,
May 2006 in “Genes & Development” Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.
90 citations
,
October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
57 citations
,
February 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.
6 citations
,
September 2019 in “Skin pharmacology and physiology” RCS-01 therapy is safe and may improve skin structure by affecting gene expression.
1 citations
,
October 2023 in “Egyptian Journal of Immunology” PCOS is linked to low-grade chronic inflammation.
105 citations
,
August 2010 in “Pharmacology & therapeutics” Formyl-peptide receptor agonists could be new anti-inflammatory drugs.