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Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

research Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride

21 citations , January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men

research The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen and Sexual Function in Healthy Young Men

72 citations , April 2008 in “The Journal of urology/The journal of urology”

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

research The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit–risk assessment of finasteride and dutasteride

66 citations , June 2013 in “Journal of Dermatological Treatment”

Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome

40 citations , March 2016 in “The Journal of Clinical Endocrinology & Metabolism”

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite

research Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite

39 citations , April 2007 in “Therapeutic Drug Monitoring”

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

research Safety concerns regarding 5α reductase inhibitors for the treatment of androgenetic alopecia

33 citations , April 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity”

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

research Finasteride: The First 5α-Reductase Inhibitor

23 citations , July 1993 in “Pharmacotherapy”

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

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