Search

everythinglearnresearchcommunity

for

Search:↓

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.

Taking spironolactone and linestrenol for androgen excess can lead to lower bone density in young women.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.

Hormonal status from androgen deprivation therapy may affect COVID-19 severity in men.

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Androgens can both increase and decrease hair growth in different parts of the body.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Lower SHBG levels may increase the risk of PCOS.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.