2 citations
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January 2014 in “International Journal of Endocrinology” Women with a certain type of tumor had higher levels of pregnancy hormone and male hormones, which decreased after treatment.
947 citations
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February 2004 in “The Journal of Clinical Endocrinology and Metabolism” Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.
402 citations
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August 2011 in “Cancer research” Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
253 citations
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March 2006 in “The Journal of Clinical Endocrinology and Metabolism” Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.
251 citations
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October 2014 in “The Journal of Clinical Endocrinology & Metabolism” The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.
211 citations
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May 2013 in “Journal of Nutrition Health & Aging” MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.
186 citations
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July 1998 in “Journal of Cutaneous Medicine and Surgery” Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.
182 citations
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June 2002 in “Journal of Neuroscience” Androgens can help prevent memory problems caused by apoE4.
165 citations
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December 2002 in “Molecular and Cellular Endocrinology” Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.
135 citations
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March 1984 in “Fertility and sterility” Higher levels of unbound testosterone are linked to increased insulin resistance, especially in women with polycystic ovary syndrome.
105 citations
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January 2009 in “Medicine” Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.
93 citations
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February 2009 in “Annals of the New York Academy of Sciences” 5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.
93 citations
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June 2001 in “The Journal of Clinical Endocrinology and Metabolism” Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.
68 citations
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April 2014 in “Journal of Molecular Endocrinology” The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
62 citations
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August 2018 in “Frontiers in Endocrinology” Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.
53 citations
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May 1986 in “Clinics in endocrinology and metabolism” Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.
51 citations
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January 1989 in “Journal of Investigative Dermatology” Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.
48 citations
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February 2008 in “Nutrition in Clinical Practice” Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.
47 citations
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October 2016 in “Molecular and Cellular Endocrinology” Androgens prevent hair growth by changing Wnt signals in cells.
47 citations
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December 2000 in “Archives of Dermatological Research” Androgens significantly affect female hair loss, and hormonal treatments may help.
45 citations
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April 2018 in “Nature Reviews Urology” Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.
45 citations
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January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
44 citations
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May 2012 in “Endocrinology” High levels of androgens during early development may cause PCOS-like symptoms.
44 citations
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January 2008 in “Fertility and Sterility” Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.
37 citations
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June 2011 in “Journal of Cellular Biochemistry” Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.
36 citations
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November 1961 in “Archives of Dermatology” The document suggests that the traditional understanding of hair growth cycles and alopecia may be inaccurate and that blood supply plays a significant role in hair growth and loss.
34 citations
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October 2018 in “Journal of The American Academy of Dermatology” Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.
31 citations
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November 2014 in “Journal of Endocrinological Investigation” Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.
30 citations
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March 2011 in “Australasian Journal of Dermatology” Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.
29 citations
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July 2009 in “BJU international” Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.