9 citations
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August 2000 in “Journal of Periodontal Research” Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
108 citations
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April 2004 in “Medicinal Research Reviews” Steroid sulfatase inhibitors could help treat hormone-related disorders and cancers.
54 citations
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May 2015 in “Endocrinology” Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.
1 citations
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January 2003 in “Expert Opinion on Therapeutic Patents” Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.
2 citations
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March 2012 in “Nature Reviews Endocrinology” The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.
8 citations
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October 2002 in “Journal Of Clinical Periodontology” Levamisole and finasteride can reduce DHT production, potentially preventing phenytoin-induced gum overgrowth.
47 citations
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August 2000 in “Endocrine Reviews” The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.
31 citations
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January 1995 in “The American journal of medicine” Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.
30 citations
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April 2007 in “Dermatologic Clinics” The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.
55 citations
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June 2012 in “Steroids” Testosterone affects vascular cells directly without converting to estradiol.
3 citations
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January 2016 in “Elsevier eBooks” Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
Androgenetic alopecia, or hair loss, is caused by genetic factors and hormones, with different mechanisms in men and women, and can be linked to insulin resistance and polycystic ovary syndrome.
21 citations
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August 2001 in “PubMed” Finasteride helps hair growth by reducing DHT levels.
29 citations
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July 2009 in “BJU international” Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.
The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.
15 citations
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August 2016 in “Current Urology Reports” Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.
41 citations
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July 2001 in “PubMed” Estrogens can reduce DHT production in hair follicles, but are less effective than finasteride and progesterone.
12 citations
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April 2020 in “Medical hypotheses” Men on 5-alpha-reductase inhibitors might have worse COVID-19 outcomes.
43 citations
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August 2010 in “Expert Opinion on Investigational Drugs” Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.
53 citations
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July 2014 in “American Journal of Physiology-Endocrinology and Metabolism” Testosterone boosts red blood cell production and changes iron metabolism without needing dihydrotestosterone.
4 citations
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April 2002 in “Medical Hypotheses” Hormones cause hair loss by affecting cell growth and weakening cell attraction.
56 citations
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December 2002 in “The Journal of Clinical Endocrinology & Metabolism” Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.
22 citations
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April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
Women with a certain type of hair loss have more copper in the back of their head than the front, and treatment can normalize hair but not copper levels.
22 citations
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March 2018 in “American Journal of Clinical Dermatology” New acne treatments show promise as alternatives to traditional therapies.
Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.
5 citations
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September 2011 in “Bioorganic & Medicinal Chemistry Letters” Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.
9 citations
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March 1991 in “Endocrinology” Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.
14 citations
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December 2013 in “Experimental Dermatology” The T-zone on the face has more androgen receptors and produces more oil than the U-zone.
November 2020 in “Elsevier eBooks” Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.