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GlossaryAndrogen Signaling

process where male hormones bind to cell receptors

Androgen signaling refers to the process by which androgens, which are male hormones like testosterone, bind to specific receptors in cells to regulate various biological functions. This signaling pathway is crucial for the development and maintenance of male characteristics, but it also plays a role in conditions like androgenetic alopecia (pattern hair loss) by affecting hair follicle health and growth.

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Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia

95 citations , January 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

46 citations , June 2015 in “Journal of Investigative Dermatology”

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Regulation of Masculinization: Androgen Signaling for External Genitalia Development

research Regulation of masculinization: androgen signalling for external genitalia development

45 citations , April 2018 in “Nature Reviews Urology”

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

research Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia

39 citations , March 2018 in “Archives of Dermatological Research”

Androgens may block hair growth signals, targeting this could treat hair loss.

research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

139 citations , December 2020 in “Cell Stem Cell”

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

3 citations , January 2024 in “Frontiers in Endocrinology”

Androgens can affect glucocorticoid signaling in specific mouse brain areas.

research Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells

2 citations , January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Androgen signaling reduces Wnt activity, affecting prostate stem cell growth.

research Androgen Signaling in Sertoli Cells

January 2014 in “theses.fr (ABES)”

Androgens regulate Sertoli cells and affect fertility through specific receptors and coregulators.

research Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling

March 2023 in “Natural product sciences”

Celtis choseniana may help treat hair loss by reducing androgen effects and boosting hair growth signals.

research Androgen receptor signaling as a new target for intervention in acute myeloid leukemia

September 2025 in “Blood Advances”

Targeting androgen receptor signaling may improve acute myeloid leukemia treatment.

Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

research Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations , January 2022 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.

Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation

research 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation

September 2019 in “Journal of Investigative Dermatology”

BMPs are important for hair growth and can counteract the negative effects of androgens on hair follicle stem cells.

Hair Thickness Growth Effect of Adenosine Complex in Male and Female Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

research Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

June 2024 in “International journal of molecular sciences”

Adenosine complex helps increase hair thickness and density in hair loss.

research Estrogen and androgen signaling in the pathogenesis of BPH

149 citations , January 2011 in “Nature reviews. Urology”

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

research Stauntonia hexaphylla Extract Ameliorates Androgenic Alopecia by Inhibiting Androgen Signaling in Testosterone-induced Alopecia Mice

January 2023 in “Iranian Journal of Pharmaceutical Research”

Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.

research Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling

14 citations , June 2022 in “Neuroscience”

research Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling

56 citations , July 2014 in “PloS one”

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

research Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling

January 2025 in “Clinical and Translational Medicine”

A specific RNA can help hair growth in baldness by boosting stem cell activity.

research Androgens and androgen receptor action in skin and hair follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

research Visualising Androgen Receptor Activity in Male and Female Mice

89 citations , August 2013 in “PloS one”

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

research Androgen Action in the Ovary

62 citations , August 2018 in “Frontiers in Endocrinology”

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia

47 citations , October 2016 in “Molecular and Cellular Endocrinology”

Androgens prevent hair growth by changing Wnt signals in cells.

research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage

30 citations , November 2013 in “PLOS ONE”

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

research Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring

21 citations , July 2019 in “Cardiovascular Research”

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo

research Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo

February 2026 in “International Journal of Molecular Sciences”

Silencing SFRP1 alone promotes hair growth, but adding DKK1 does not help.

research Role of FGFR2-signaling in the pathogenesis of acne

63 citations , May 2009 in “Dermato-endocrinology”

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

research Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

18 citations , February 2018 in “International Journal of Molecular Sciences”

PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.

research Androgen excess: a hallmark of polycystic ovary syndrome

December 2023 in “Frontiers in endocrinology”

Excess androgens may cause PCOS, not just be a symptom.

research Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla

122 citations , November 2010 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

research Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens

51 citations , August 2012 in “Differentiation”

Mouse genital development depends on male or female hormones for specific features.