research Changes of androgens levels in menopausal women
Menopausal women have higher androgen levels, which can cause symptoms like facial hair growth and low sexual desire.
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research Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole
Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
research FINASTERIDE INHIBITS 5?-REDUCTASE ACTIVITY IN HUMAN DERMAL FIBROBLASTS: PREDICTION OF ITS THERAPEUTIC APPLICATION IN ANDROGEN-RELATED SKIN DISEASES
Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
research 5α‐Reductase Isozymes and Androgen Actions in the Prostate
5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.
research Regulation of masculinization: androgen signalling for external genitalia development
Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.
research Androgen treatment in women
Testosterone therapy can help improve sexual function, mood, and bone density in women with low androgen levels, but more research is needed on long-term safety.
research Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone
Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.
research Androgen receptor–mediated inhibition of cutaneous wound healing
Lowering testosterone speeds up wound healing in male mice.
research Revising the role of the androgen receptor in breast cancer
The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
research Androgen receptors and their biology
Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.
research 6 Peripheral androgens and the role of androstanediol glucuronide
Androstanediol glucuronide is a reliable marker for hirsutism in women.
research Basics of androgen synthesis and action
Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.
research Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalis
Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.
research Androgenic alopecia: A counterproductive outcome of the anabolic effect of androgens
Male pattern baldness is an unintended side effect of the body's use of androgens for muscle growth, especially in those genetically prone to it.
research Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle
Androgens promote beard growth but cause hair loss in androgenetic alopecia, with TGF-β1 as a potential treatment target.
research Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia
Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
research Understanding Causes of Hair Loss in Women
The conclusion is that hair loss in women is caused by a mix of hormonal, environmental, and genetic factors, and treatments should target these various causes.
research Probing androgen receptor co-factor selectivity profiles: a chemical tool to determine cross-talk between androgen receptor and β-catenin in vivo
PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.
research Androgen deprivation therapy and hormonal status in men with COVID-19
Hormonal status from androgen deprivation therapy may affect COVID-19 severity in men.
research The role of androgen and androgen receptor in skin-related disorders
Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage
Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
research The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications
Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.
research Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia
Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function
A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.
research Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life
Male hormones cause different growth in identical human hair follicles due to their unique epigenetic characteristics.
research Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood
Excess maternal androgens can cause heart problems in offspring.
research Androgen actions on the human hair follicle: perspectives
Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.
research Chapter 23. Therapeutic Control of Androgen Action
Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.
research COVID‐19, androgens, and androgenic alopecia
COVID-19 may worsen with androgens; anti-androgen drugs could help.