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GlossaryAndrogenic Activity

hormonal effects influencing male traits and hair growth

Androgenic activity refers to the effects that androgens, a group of hormones like testosterone, have on the body. These hormones influence the development and maintenance of male characteristics, such as facial hair and a deeper voice, but they also play a role in hair growth and loss, muscle mass, and overall skin health. In the context of hair, high androgenic activity can lead to conditions like androgenic alopecia, commonly known as male or female pattern baldness.

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research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring

20 citations , September 2005 in “Endocrinology”

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Neonatal Inhibition of Androgen Activity Alters the Programming of Body Weight and Orexinergic Peptides Differentially in Male and Female Rats

research NEONATAL INHIBITION OF ANDROGEN ACTIVITY ALTERS THE PROGRAMMING OF BODY WEIGHT AND OREXINERGIC PEPTIDES DIFFERENTIALLY IN MALE AND FEMALE RATS

February 2024 in “Brain research bulletin”

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.

research Androstanediolglucuronide: A parameter for peripheral androgen activity before and during therapy with cyproterone acetate

8 citations , April 1991 in “European journal of endocrinology”

3α-AdiolG is a good marker for androgen activity in women with excessive hair growth and decreases with anti-androgen treatment.

research The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific

12 citations , June 2013 in “The Prostate”

Dutasteride and finasteride affect different cell types differently.

research Adrenal and Gonadal Activity, Androgen Concentrations, and Adult Height Outcomes in Boys With Silver-Russell Syndrome

1 citations , December 2019 in “Frontiers in endocrinology”

Higher androgen levels during puberty are linked to shorter adult height in boys with Silver-Russell syndrome.

research Hair follicle sulfotransferase activity and effectiveness of oral minoxidil in androgenetic alopecia

1 citations , July 2024 in “Journal of Cosmetic Dermatology”

Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.

research 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level

7 citations , August 2010 in “Medicinal Chemistry Research”

Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.

research Antifungal activity and hair growth stimulation of purple sweet potato leaf fraction (Ipomoea batatas (L.) Lamk) and its molecular mechanism through androgen receptor inhibition

May 2024 in “Pharmacia/Farmaciâ”

Purple sweet potato leaf extracts can help treat hair loss and fungal infections.

Reversal of Androgenetic Alopecia by Topical Ketoconazole: Relevance of Anti-Androgenic Activity

research Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity

38 citations , September 2006 in “Journal of Dermatological Science”

Ketoconazole lotion can improve hair regrowth for some people with androgenetic alopecia.

research Pharmacological Profile of 9,11-Dehydrocortexolone 17α-Butyrate (CB-03-04), a New Androgen Antagonist with Antigonadotropic Activity

1 citations , December 2011 in “Arzneimittelforschung”

CB-03-04 shows promise as a treatment for prostate issues due to its strong anti-androgen effects.

Early Androgen Activity After Birth Determines the Hypothalamic Expression of Androgen and Estrogen Receptors in Adulthood in Female but Not in Male Rats

research Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

July 2025 in “Reproductive Biology and Endocrinology”

Early androgen exposure affects hormone receptor expression in adult female rats' brains, but not in males.

Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia

research Sulfotransferase SULT1A1 activity in hair follicle, a prognostic marker of response to the minoxidil treatment in patients with androgenetic alopecia: a review

November 2020 in “Postepy Dermatologii I Alergologii”

Sulfotransferase SULT1A1 activity may predict minoxidil treatment success for hair loss.

Anti-Alopecia Activity of Coumarin Derivatives from Merremia Peltata Leaves and Their Binding to Androgen Receptors: A Molecular Study

research Anti-Alopecia Activity of Coumarin Derivatives Isolated from Merremia peltata Leaves and Computational Study of Their Binding to Androgen Receptors Using Molecular Docking and Molecular Dynamic Simulation

2 citations , April 2023 in “Pharmaceuticals”

Scopolin and scopoletin from Merremia peltata leaves may help treat hair loss and showed promising results in rabbit tests.

research Activity and Safety of Cinchonine Nanostructured Lipid Carriers as a Hair Growth Stimulant in Mice Model of Androgenetic Alopecia

June 2023 in “Sains Malaysiana”

Cinchonine Nanostructured Lipid Carriers serum safely and effectively stimulates hair growth and increases the number and size of hair follicles.

research The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

May 2023 in “Scientific Reports”

The seed extract of Lepidium sativum L. can potentially treat hair loss, showing effects similar to 5% minoxidil.

research Modulation of Androgen Receptor Transcriptional Activity

February 2009 in “RePub (Erasmus University Rotterdam)”

Androgen receptor activity is influenced by hormones, co-factors, modifications, and mutations.

research Lack of androgen receptor transcriptional activity in human keratinocytes

30 citations , June 2000 in “Journal of dermatological science”

Human keratinocytes do not naturally respond to androgens.

Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia

research Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil in the treatment of female androgenetic alopecia

20 citations , April 2014 in “Dermatologic Therapy”

Sulfotransferase in hair follicles helps predict how well minoxidil works for female hair loss.

Novel Topical Booster Enhances Follicular Sulfotransferase Activity in Patients with Androgenetic Alopecia: A New Strategy to Improve Minoxidil Response

research Novel topical booster enhances follicular sulfotransferase activity in patients with androgenetic alopecia: a new strategy to improve minoxidil response

3 citations , May 2020 in “Journal of The European Academy of Dermatology and Venereology”

Topical booster improves hair loss treatment effectiveness.

research Anti-androgenic activities of Ganoderma lucidum

70 citations , July 2005 in “Journal of Ethnopharmacology”

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

research Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

64 citations , March 2006 in “Food Chemistry”

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

research Visualising Androgen Receptor Activity in Male and Female Mice

89 citations , August 2013 in “PloS one”

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Evaluation of Hair Growth Promoting Activity of Sansevieria Trifasciata P. on Androgenic Alopecia in Male Rabbits

research Evaluation of Hair Growth Promoting Activity of Sansevieria Trifasciata P. on Alopecia Androgenic Rabbit Male

January 2021 in “International journal of pharmaceutical research”

Sansevieria trifasciata P. extracts, especially the ethyl acetate fraction, effectively promote hair growth in male rabbits with hair loss.

research Prenatal and adult androgen activities in alcohol dependence

63 citations , April 2017 in “Acta psychiatrica Scandinavica”

Higher prenatal and adult androgen levels are linked to alcohol dependence and withdrawal severity.

research Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

2 citations , January 2022 in “Skin Pharmacology and Physiology”

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Supplementary Material for: Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

research Supplementary Material for: Dexamethasone, a synthetic glucocorticoid, induces the activity of androgen receptor in human dermal papilla cells

January 2022 in “Figshare”

Dexamethasone increases androgen receptor activity in scalp cells, which might explain stress-related hair loss.

research Mechanisms that regulate androgen receptor transcriptional activity

August 2019 in “Carolina Digital Repository (University of North Carolina at Chapel Hill)”

DHT enhances androgen receptor activity more than testosterone, and MAGE-11 influences this activity through specific interactions.

research Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells

2 citations , January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Androgen signaling reduces Wnt activity, affecting prostate stem cell growth.

Synthesis and Structure–Activity Studies of Side-Chain Derivatized Arylhydantoins for Investigation as Androgen Receptor Radioligands

research Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands

18 citations , April 2001 in “Bioorganic & Medicinal Chemistry Letters”

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Synthesis and Structure–Activity Investigation of Iodinated Arylhydantoins and Arylthiohydantoins for Development as Androgen Receptor Radioligands

research Synthesis and structure–activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands

6 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.