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Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

research Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells

19 citations , September 2011 in “Journal of Dermatological Science”

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

Alfatradiol (0.025%) - An Effective and Safe Treatment Option for Androgenetic Alopecia in Women and Men

research Alfatradiol (0,025 %) - Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern

10 citations , December 2005 in “Aktuelle Dermatologie”

Alfatradiol (0.025%) is an effective and safe treatment for hair loss in both women and men.

research Topical Antiandrogens

11 citations , January 1985 in “Archives of Dermatology”

Topical antiandrogens might treat skin issues like hair growth, balding, and acne, but finding effective treatments without side effects is challenging.

research Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?

1 citations , September 2016 in “Actas Dermo-Sifiliográficas”

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.

research Characterizing the role of facial hair in gender identity and expression among transgender men

3 citations , August 2021 in “Journal of the American Academy of Dermatology”

Facial hair is crucial for transgender men's gender identity and transition.

research Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone

1 citations , June 2021 in “Singapore Medical Journal”

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

Cutaneous Manifestations and Their Relationship with Serum Testosterone and DHEAS Levels in Women with Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study

research Cutaneous Manifestations and Their Relationship with Serum Testosterone and DHEAS Levels in Women with Polycystic Ovary Syndrome: A Cross‑Sectional Clinical Study

February 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Hirsutism and acne indicate high androgen levels in women with PCOS, suggesting early treatment can help.

research Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomised, Placebo-Controlled Phase III Trial

February 2009 in “Endocrinology”

DHEA therapy improves pubic hair growth and psychological well-being in girls with central adrenal insufficiency.

research Up-regulation of androgen receptor by heat shock protein 27 and miR-1 induces pathogenesis of androgenic alopecia.

January 2022 in “PubMed”

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

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