research Androgenic hormone profile in patients with androgenetic alopecia
Androgenetic alopecia in males is linked to hormone levels and the enzyme 5-alpha reductase.
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research Clinical biochemistry of dihydrotestosterone
Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
research SUN-118 A Case of Anastrozole Induced Hyperandrogenism
Anastrozole can cause increased testosterone, leading to symptoms like hair growth and thinning.
research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
research Pre-receptor regulation of the androgen receptor
Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.
research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase
Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.
research Intracrine androgen biosynthesis, metabolism and action revisited
The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
research (282) CONSEQUENCES OF ANABOLIC-ANDROGENIC STEROID ABUSE IN MALES: RESULTS FROM A META-ANALYSIS STUDY
Anabolic-androgenic steroids harm male hormone levels, sperm, metabolism, and can cause acne, hair loss, and breast growth.
research finasteride, n.
research ST008 Male androgenetic alopecia: A new treatment paradigm
New treatment improves male hair loss.
research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors
Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
research Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes
Neurosteroids may help treat disorders with too much dopamine activity.
research Androgen Biosynthesis Inhibitors and Androgen Receptor Antagonists
Anti-androgen drugs can treat conditions like prostate cancer and male pattern baldness by blocking effects of testosterone and DHT.
research Androgen antagonists in androgen target tissues
Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin
Sebocytes play a key role in controlling androgen levels in human skin.
research 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line
Dihydrotestosterone (DHT) increases oil production in skin cells by activating mTOR, and mTOR inhibitors can reduce this effect.
research Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells
Androgen signaling reduces Wnt activity, affecting prostate stem cell growth.
research I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells
Vitamin C derivative reduces hair loss-related protein in cells.
research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
New steroid derivatives show promise as anticancer agents, even against resistant cells.
research Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation
Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.
research Hair growth promoting effects of andrographolide from Andrographis paniculata (Burm.f.) Wall. ex Nees : In vitro, in vivo, and molecular docking studies
Andrographolide from Andrographis paniculata promotes hair growth and could be a natural treatment for hair loss.
research Intracrine and Myotrophic Roles of 5α-Reductase and Androgens
Muscles can make their own androgens, which may help muscle growth.
research Bicalutamide
research Finasteride: the first 5 alpha-reductase inhibitor.
research ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA
Androgens, like DHT, affect hair growth and treatments like finasteride may help.
research Prefrontal 5α-reductase 2 mediates male-specific acute stress response
5α-reductase 2 is crucial for stress response in male rats.
research FINASTERIDE AND PSA
research Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths
PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.
research Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism
Men with high testosterone may have higher morning blood pressure, unlike those with high DHT.