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Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

Androgenic Alopecia in Females: Diagnosis and Treatment

research Androgenic Alopecia

14 citations , July 1987 in “Dermatologic Clinics”

The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.

Early Embryonic Exposure of Freshwater Gastropods to Pharmaceutical 5-Alpha-Reductase Inhibitors Results in a Surprising Open-Coiled 'Banana-Shaped' Shell

research Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell

13 citations , November 2019 in “Scientific reports”

Certain drugs change freshwater snail shells to a "banana" shape.

research Relationship Between Steroid Hormones and Metabolic Profile in Women With Polycystic Ovary Syndrome

13 citations , March 2019 in “Physiological Research”

Overweight women with PCOS have higher levels of certain hormones that could indicate a higher risk of heart and metabolic problems.

research Finasteride and androgenic alopecia; from therapeutic options to medical implications

13 citations , March 2019 in “Journal of Dermatological Treatment”

Finasteride can treat hair loss, but may have side effects; evaluate and inform patients of risks.

research Adult Acne: Prevalence and Portrayal in Primary Healthcare Patients, in the Greater Porto Area, Portugal

13 citations , September 2016 in “Acta Médica Portuguesa”

Many adults in Porto have acne, but few know or treat it.

Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat steroid 5α-reductase kinetic characteristics: Extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates

13 citations , August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

research Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation

12 citations , June 2019 in “Psychoneuroendocrinology”

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Testosterone-Like Immunoreactivity in Hair Measured in Minute Sample Amounts: A Competitive Radioimmunoassay with an Adequate Limit of Detection

research Testosterone-like immunoreactivity in hair measured in minute sample amounts - a competitive radioimmunoassay with an adequate limit of detection

12 citations , December 2017 in “Scientific reports”

The new test can measure very small amounts of testosterone in hair, and grinding the hair up first gives more accurate results.

research Molecular basis of androgen action on human sexual desire

12 citations , September 2017 in “Molecular and Cellular Endocrinology”

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

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