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The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

New steroids were effective in blocking male hormone receptors in hamster prostates.

The medication combination did not affect glucose tolerance but increased some cholesterol levels due to its estrogen component.

Dutasteride is the most effective for hair loss but may cause sexual and mental side effects.

Dutasteride 0.5mg improves hair growth in 78% of people with hair loss, but may cause sexual problems in some.

Finasteride and Dutasteride can improve hair growth in male baldness but may cause temporary sexual dysfunction and possibly affect fertility.

The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.

Low and ultralow doses of flutamide can cause liver damage in young women with high androgen levels, regardless of dose or birth control use, with higher risk for those with higher BMI and liver enzyme levels before treatment.

Dutasteride improved hair density and thickness in men not helped by finasteride, with minimal side effects.

Dutasteride likely doesn't harm wild fish due to low environmental levels, but more research is needed on bioaccumulation.

ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.

Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.

Androgen self-administration might be controlled by membrane receptors, not nuclear ones.

Genetic profiling can improve androgenetic alopecia treatment by predicting drug response and minimizing side effects.

Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.

Hormonal status from androgen deprivation therapy may affect COVID-19 severity in men.

A new, safer method to make finasteride from progesterone is effective for industrial use.

THSG from a Chinese plant helps with aging and related diseases.

Compound 15a was effective in inhibiting 5α-reductase.

Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Family history and elevated DHEA-S levels are linked to more severe hair loss.

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by affecting androgen functions and suppressing certain hormones.

Ethinylestradiol/chlormadinone acetate may be an effective and well-tolerated treatment for skin conditions caused by excess androgens.

The combination of tadalafil and finasteride improves urinary symptoms and erectile function in men with enlarged prostates.

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.