research Endocrine treatment of benign prostatichypertrophy: Current concepts
New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.
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research Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne
A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.
research GC-MS determination of steroids related to androgen biosynthesis in human hair with pentafluorophenyldimethylsilyl–trimethylsilyl derivatisation
The method accurately measures certain steroids in human hair, showing different levels in males and females.
research Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study
Going to bed late may increase hormones and decrease muscle in women with PCOS.
research Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice
Progesterone helps adult male mice grow more neurons and improves memory.
research Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines
Androgen measurement helps diagnose PCOS, but accuracy varies, needing standard methods.
research Progesterone Promotes the Survival of Newborn Neurons in the Dentate Gyrus of Adult Male Mice
Progesterone helps adult male mice's brain cells survive and improves learning and memory.
research [Long-term treatment of virilized women with cyproterone acetate (author's transl)].
Cyproterone acetate effectively treats virilized women, especially under 35, despite some side effects.
research Oral contraceptives and risk of breast cancer in women aged 20–54 years
Long-term use of oral contraceptives, especially starting before age 20, may increase the risk of early-onset breast cancer.
research The dose‐response of percutaneous oestradiol implants on the skeletons of postmenopausal women
Higher doses of oestradiol implants improve bone density in postmenopausal women.
research A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea
Cabergoline is more effective and has fewer side effects than bromocriptine for treating women with hyperprolactinemic amenorrhea.
research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research Finasteride treatment for one year in 35 hirsute patients
Finasteride safely reduces excessive hair growth in women.
research Co-secretion of testosterone and cortisol by a functional adrenocortical oncocytoma
A woman's rare adrenal tumor caused high testosterone and cortisol levels, which normalized after the tumor was removed.
research Is the metabolism of testosterone to 5α-dihydrotestosterone required for androgen action in the skin?
Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.
research Plasma androsterone/epiandrosterone sulfates as markers of 5α-reductase activity: Effect of finasteride in normal men
Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.
research An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism
A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.
research Sexual Function and Depressive Symptoms in Young Women With Nonclassic Congenital Adrenal Hyperplasia
Young women with nonclassic congenital adrenal hyperplasia may experience worse sexual function and mild depression compared to healthy women.
research Proscar@ (Finasteride) inhibits 5α-reductase activity in the ovaries and testes of Lytechinus variegatus Lamarck (Echinodermata: Echinoidea)
Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.
research Androgens and the Menopause
Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.
research Additive in vivo growth-inhibitory effects of flutamide and finasteride on androgen-sensitive Shionogi 115 carcinoma
Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.
research Sexual function in women with androgen excess disorders: classic forms of congenital adrenal hyperplasia and polycystic ovary syndrome
Women with congenital adrenal hyperplasia (CAH) have more sexual function issues than those with polycystic ovary syndrome (PCOS), but physical activity can improve sexual functioning in all women.
research Serum 1, 25-dihydroxy vitamin D- vitamin D3- among obese Egyptian women with polycystic ovary syndrome
Obese women with PCOS have lower vitamin D levels.
research Comparison of Finasteride, Metformin, and Finasteride Plus Metformin in PCOS
Finasteride and metformin both help treat PCOS, but using them together works best.
research Serum C-19 steroid sulphates in females with clinical hyperandrogenism
Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.
research British Menopause Society Tools for Clinicians: Testosterone replacement in menopause.
Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.
research Clomiphene Citrate versus Letrozole for Ovulation Induction in PCOS: A Comparative Study
Letrozole is better for single follicle development and endometrial thickness in PCOS, with no significant difference in pregnancy rates compared to clomiphene.
research Lack of association between clinical and biochemical hyperandrogenism in patients with polycystic ovary syndrome
Clinical signs of excess male hormones and actual hormone levels in the blood do not always match in women with polycystic ovary syndrome.
research Intracrinology and Testosterone Pellet Therapy: An Enzyme-Aware, Symptom-Driven Approach to Hormone Optimization in Aging
Testosterone pellet therapy may better address hormone imbalances in aging by focusing on local hormone production and symptom relief.