research Female Androgenetic Alopecia: An Update on Diagnosis and Management
FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.
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research Steroid 5α-Reductase Inhibitors
New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
research Evidence-based approach to cutaneous hyperandrogenism in women
The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.
research Hirsutism: Diagnosis and management
The conclusion is that hirsutism should be diagnosed and treated because it affects quality of life and may signal other health problems.
research Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone
Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.
research Spironolactone Therapy for Hirsutism in a Hyperandrogenic Woman
Spironolactone may help reduce excessive hair growth in women with high male hormone levels.
research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity
Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
research Consecutive Cyproterone Acetate and Estradiol Treatment in Late-Pubertal Transgender Female Adolescents
Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.
research In vitro bioassays for androgens and their diagnostic applications
In vitro bioassays are better than traditional methods for measuring androgen activity but aren't ready for routine use yet.
research What every physician should know about polycystic ovary syndrome
Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.
research Gender-Affirming Hormone Therapy for Transgender Females
Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.
research Contemporary medical therapy for polycystic ovary syndrome
New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.
research Androgens and Anti-androgen Therapy
Antiandrogen therapy, like cyproterone acetate, effectively treats acne, hirsutism, and hair loss.
research Becker's Nevus with Ipsilateral Breast Hypoplasia: Improvement with Spironolactone
Spironolactone may help enlarge a small breast linked to Becker's nevus.
research Androgen antagonists in androgen target tissues
Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
research Contribution of androgens to chronic allograft nephropathy is mediated by dihydrotestosterone
Male hormones worsen kidney transplant damage, but blocking them helps.
research Interaction of spironolactone with rat skin androgen receptor
Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.
research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.
New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.
research Treatment of hirsutism with spironolactone
Spironolactone is effective and safe for treating excessive facial hair in women.
research Expression of concern: potential risk for developing severe COVID-19 disease among anabolic steroid users
Anabolic steroid users may face higher risk of severe COVID-19.
research Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring
High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.
research Female Adolescent Hair Disorders
Quick treatment of hair disorders in teenage girls is important because of the emotional effects.
research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives.
New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
research Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women
The spironolactone cream did not reduce hair growth in women with hirsutism.
research Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size
Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.
research Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3
The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
research Germacrone and sesquiterpene-enriched extracts from Curcuma aeruginosa Roxb. increase skin penetration of minoxidil, a hair growth promoter
Certain extracts from Curcuma aeruginosa Roxb. and germacrone can boost the skin's absorption of minoxidil, a hair growth promoter, making it more effective.
research Inhibitory Effects of Serenoa repens on the Kinetic of Pig Prostatic Microsomal 5α-Reductase Activity
Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.
research Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota: Comparative study of Poria cocos polysaccharides and finasteride in treating chronic prostatitis
Poria cocos polysaccharides and finasteride both help treat chronic nonbacterial prostatitis, but Poria cocos polysaccharides also improve gut health.
research Comparison Between Two Different Hamster Models used for the Determination of Testosterone and Finasteride Activity
Young and adult hamsters both respond similarly to testosterone and finasteride treatments, but young hamsters aren't good for testing the inhibitory activity of a specific enzyme.