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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

research 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

TYK2 inhibition may help treat alopecia areata by promoting hair growth and reducing immune response.

Bitemporal Alopecia Areata: Case Reports and Diagnostic Challenges

research Bitemporal alopecia areata

1 citations , March 2020 in “Australasian Journal of Dermatology”

The paper concludes that recognizing bitemporal alopecia areata is important for early treatment and preventing its progression.

research Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus

6 citations , April 2016 in “Australasian journal of dermatology”

Renal transplant patients on tacrolimus and sirolimus may develop acne keloidalis nuchae.

research The coudability sign of alopecia areata: the real story

9 citations , March 2011 in “Clinical and experimental dermatology”

The document concludes that anticonvulsants like phenytoin may cause skin reactions by affecting tryptophan metabolism and suggests researching vitamin levels in patients with drug reactions.

Comparative Evaluation of Efficacy and Safety of Topical Methotrexate With Tretinoin Versus Betamethasone With Tretinoin in Patients of Alopecia Areata: A Prospective Randomized Double-Blind Study

research COMPARATIVE EVALUATION OF EFFICACY AND SAFETY OF TOPICAL METHOTREXATE WITH TRETINOIN VERSUS BETAMETHASONE WITH TRETINOIN IN PATIENTS OF ALOPECIA AREATA: A PROSPECTIVE RANDOMIZED DOUBLE-BLIND STUDY

October 2024 in “Asian Journal of Pharmaceutical and Clinical Research”

Topical methotrexate is more effective and as safe as betamethasone for treating alopecia areata.

The IVIG Treatment Response in Autoimmune Polyendocrine Syndromes Type 2 with Anti-GAD65 Antibody-Associated Stiff Person Syndrome: A Case Report and Literature Review

research The IVIG treatment response in autoimmune polyendocrine syndromes type 2 with anti-GAD65 antibody-associated stiff person syndrome: a case report and literature review

January 2025 in “Frontiers in Immunology”

IVIG therapy significantly improved symptoms in a patient with APS-2 and SPS.

research Abstract 5561: 20(S)-Protopanaxadiol-aglycone downregulates full-length and ligand-independent splice variants of androgen receptor

April 2011 in “Cancer Research”

20(S)-Protopanaxadiol-aglycone may help prevent and treat prostate cancer by reducing androgen receptor activity.

research Vitiligo as a Reaction to Topical Treatment with Diphencyprone

55 citations , January 1988 in “Dermatology”

Diphencyprone treatment for alopecia areata can cause vitiligo in some patients.

research Anaplasmosis concurrent with copper deficiency in a Salem Black kid

June 2024 in “Indian Journal of Veterinary Medicine”

The young goat had anaplasmosis and copper deficiency.

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