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Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

research Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption

282 citations , April 2007 in “Journal of Agricultural and Food Chemistry”

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

research Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent

32 citations , December 2000 in “Phytomedicine”

Apple-derived procyanidin B-2 can safely promote hair growth in men.

research Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study

37 citations , January 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

Apple extract called procyanidin B-2 was found to greatly increase hair growth.

research Procyanidin B-2 and the hair-growing activity of proanthocyanidins

1 citations , January 2001 in “Cosmetics and toiletries”

Procyanidin B-2 from apple juice significantly increases hair growth and may be more effective than minoxidil without side effects.

research Inhibitory Effects of Apple Polyphenols on Differentiation of 3T3-L1 Cells into Adipocytes.

18 citations , January 2000 in “Food Science and Technology Research”

Apple polyphenols, especially from unripe apples, can help prevent cells from turning into fat cells.

research Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

13 citations , December 2019 in “Nutrients”

An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.

research ANNURCA APPLE EXTRACT - A BREAKTHROUGH IN ALOPECIA PHYTOTHERAPY: A LITERATURE REVIEW

February 2024 in “Archiv EuroMedica”

Annurca apple extract may help with hair growth and prevent hair loss.

research Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

24 citations , January 2020 in “International Journal of Molecular Sciences”

Some plants with flavonoids may help treat hair loss and promote hair growth.

research Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth

32 citations , January 2000 in “Skin pharmacology and physiology”

Certain substances that block a specific protein help promote hair growth.

A Semisynthetic Approach for the Simultaneous Reaction of Grape Seed Polymeric Procyanidins with Catechin and Epicatechin to Obtain Oligomeric Procyanidins in Large Scale

research A semisynthetic approach for the simultaneous reaction of grape seed polymeric procyanidins with catechin and epicatechin to obtain oligomeric procyanidins in large scale

9 citations , April 2019 in “Food Chemistry”

Created large amounts of grape seed compounds using a new method.

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth in a Randomized Clinical Trial

research Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial

27 citations , September 2017 in “Journal of Medicinal Food”

Annurca apple supplement safely increases hair growth and keratin in humans.

research Toxicological Studies on Procyanidin B-2 for Extern?al Application as a Hair Growing Agent

30 citations , May 1999 in “Food and chemical toxicology”

Procyanidin B-2 is safe to use on skin as a hair growth product.

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

19 citations , November 2018 in “Nutrients”

Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.

A Comprehensive Narrative Review on the Health Benefits of Apples and Their Derivatives: Focus on Cardiovascular Disease Prevention, Metabolic Regulation, and Chronic Disease Mitigation

research A Comprehensive Narrative Review Designed to Evaluate the Health Benefits of Apples and Their Derivatives, with a Focus on Cardiovascular Disease (CVD) Prevention, Metabolic Regulation, and Chronic Disease Mitigation

October 2025 in “International Journal For Multidisciplinary Research”

Eating apples regularly can improve heart health and help prevent chronic diseases.

Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1

research Procyanidin B‐3, isolated from barley and identified as a hair‐growth stimulant, has the potential to counteract inhibitory regulation by TGF‐β1

36 citations , December 2002 in “Experimental dermatology”

Barley extract, specifically procyanidin B-3, can promote hair growth and counteract growth inhibition.

Early Plant Growth and Biochemical Responses Induced by Azospirillum Brasilense Sp245 Lipopolysaccharides in Wheat (Triticum Aestivum L.) Seedlings Are Attenuated by Procyanidin B2

research Early plant growth and biochemical responses induced by Azospirillum brasilense Sp245 lipopolysaccharides in wheat (Triticum aestivum L.) seedlings are attenuated by procyanidin B2

11 citations , March 2018 in “Protoplasma”

Lipopolysaccharides boost wheat seedling growth, but procyanidin B2 weakens this effect.

A Randomized Double-Blind Placebo-Controlled Clinical Trial to Evaluate the Effect of an Annurca Apple Supplement Formula in Androgenic Alopecia

research A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia

May 2023 in “Journal of Applied Cosmetology”

The Annurca apple supplement significantly improved hair growth in people with hair loss.

research Does an apple a day keep away diseases? Evidence and mechanism of action

2 citations , June 2023 in “Food science & nutrition”

Eating apples can help prevent heart disease, cancer, and other conditions because they have healthy plant chemicals.

research Hair Loss

January 2015 in “Springer eBooks”

Some alternative treatments may help with hair loss, but more evidence is needed to confirm their effectiveness.

research Cosmeceuticals for Hair Loss and Hair Care

November 2013

Some plant-based ingredients may help with hair growth and care, but more research is needed to confirm their effectiveness.

research The first clinical trial of topical application of procyanidin B‐2 to investigate its potential as a hair growing agent

26 citations , June 2001 in “PTR. Phytotherapy research/Phytotherapy research”

Procyanidin B-2 lotion might help men grow thicker hair without side effects.

research An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

1 citations , December 2022 in “Current Issues in Molecular Biology”

Annurca apple extract improved hair growth in mice and could potentially prevent hair loss.

Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study

research Evaluation of the efficacy and safety of topical procyanidin b2 and placebo in the treatment of androgenetic alopecia in men; A randomized, double-blind, placebo-controlled study

January 2022 in “Turk Dermatoloji Dergisi”

Topical procyanidin B2 significantly increases hair count and is a safe treatment for male pattern baldness.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , August 2018 in “Skin appendage disorders”

Some alternative treatments for hair loss might work, but more research is needed.

research Topically used herbal products for the treatment of hair loss: preclinical and clinical studies

25 citations , July 2017 in “Archives of Dermatological Research”

Herbal products might promote hair growth with fewer side effects, but more research is needed to confirm their safety and effectiveness.

A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia

research A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

14 citations , October 2020 in “Natural Products and Bioprospecting”

Various treatments, including FDA-approved drugs, natural products, and oral supplements, can help with hair loss, but a patient's medical history and potential allergies should be considered when choosing a treatment.