research Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation
Finasteride capsules with nanoparticles improve drug delivery, solubility, stability, and effectiveness.
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480-510 / 1000+ results research The effect of St John's Wort on the pharmacokinetics and metabolism of finasteride in healthy men
research 554 Repurposing a clinical antimalarial for the therapeutic induction of lethal ER stress targeting BRAF-kinase inhibitor-resistant malignant melanoma
Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.
research Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation
Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
research 5α-Reductase Inhibitors, Chemical and Clinical Models
Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.
research Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration
Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.
research Adverse events associated with vismodegib: insights from a real-world pharmacovigilance study using the FAERS database
Vismodegib can cause muscle spasms, taste changes, hair loss, fatigue, weight loss, and possibly new issues like skin cancer, dehydration, and swallowing problems, needing close monitoring.
research Gum Arabic Enhances Hair Follicle-Targeting Drug Delivery of Minoxidil Nanocrystal Dispersions
Gum arabic improves minoxidil delivery to hair follicles, enhancing hair growth.
research Finasteride drug safety alert
Finasteride may cause depression, suicidal thoughts, and sexual side effects.
research Adiantum capillus-veneris Linn (Maidenhair fern) extract-based drug as a symptomatic treatment for COVID-19. (clinical candidate)
Maidenhair fern extract may help treat COVID-19 symptoms.
research Signal detection between 5-alpha reductase inhibitors and the risk of suicidality and depression: an international pharmacovigilance analysis
Finasteride may increase the risk of suicidality and depression, especially in younger people.
research Minoxidil overdose with hypotension effectively managed with norepinephrine, rather than dopamine
research Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats
A neurosteroid can reduce caffeine-induced anxiety in rats.
research A RANDOMIZED, PROSPECTIVE, SINGLE-BLIND CLINICAL TRIAL: COMPARATIVE STUDY OF COMPARING THE EFFICACY AND SAFETY OF DIFFERENT MINOXIDIL FORMULATIONS IN TREATING ANDROGENIC ALOPECIA
Both 5% minoxidil foam and liquid effectively treat hair loss, with foam slightly preferred.
research The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease
Finasteride reduces movement issues in Parkinson's disease rats.
research A randomized, blinded, three-arm, multicenter trial comparing the efficacy and safety of fluconazole given once daily for 3 or 6 weeks with griseofulvin given once daily for 6 weeks in pediatric patients with tinea capitis
The two lotions used day and night may be a good alternative to minoxidil for hair loss treatment with better cosmetic effects and tolerance.
research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure
Morphine increases testosterone breakdown in the rat brain and spinal cord.
research Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia
Adenosine treatment thickens hair in Caucasian men with hair loss.
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research Farmácia Serpa Pinto, Porto e Serviços Farmacêuticos do Instituto Português Oncologia do Porto Francisco Gentil, EPE, Porto
Dutasteride is more effective than finasteride for hair growth, and pregabalin effectively treats neuropathic pain.
research 27940 Assessment of treatment maintenance effects of finasteride 1 mg every other month regimen in androgenic alopecia and clinical differences according to treatment response
Finasteride 1 mg every other month effectively maintains hair growth in androgenic alopecia.
research Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay
A new plant extract from Avicennia marina could potentially be used to treat common hair loss.
research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances
The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.
research Enhanced Insights into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies
Frontal Fibrosing Alopecia needs better diagnostics and treatments, with dutasteride showing promise.
research Simultaneous Estimation of Minoxidil and Aminexil in Bulk and Pharmaceutical Formulations by Rp-Hplc Method
A new method accurately measures minoxidil and aminexil in drugs.
research A STUDY OF EFFICACY AND SAFETY OF ORAL MINOXIDIL IN MALE ANDROGENETIC ALOPECIA
Oral minoxidil effectively promotes hair growth in men with hair loss, but caution is needed for older or heart-risk patients.
research Discovery of novel 5α-reductase type II inhibitors by pharmacophore modelling, virtual screening, molecular docking and molecular dynamics simulations
A new compound may treat benign prostatic hyperplasia better than finasteride.
research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.
GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.