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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Androgen receptor inactivation delays skin cancer onset and reduces incidence in mice, with gender differences in susceptibility.

Targeting amphiregulin may improve treatment for fibrosis and cancer.

RAR-gamma 1 is important for normal skin maintenance and differentiation.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Androgen receptor abnormalities may contribute to hair loss in androgenetic alopecia.

A new treatment for hair loss shows promise with fewer side effects.

Certain genetic variants impair enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

A point mutation in the androgen receptor gene causes complete androgen insensitivity.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

We need better ways to test and understand SARMs to make safer and more effective treatments.

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.

Antisense oligonucleotides can reduce androgen receptor levels in skin cells, suggesting potential for treating skin disorders.

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.

The IRE gene is important for normal root hair growth in Arabidopsis plants.

Different Hairless isoforms affect Vitamin D receptor activity in hair regulation, with one repressing and the other stimulating it.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

The most common sign of aging at the gene level is more Ectodysplasin A2 Receptor (EDA2R) being made.

Differences in androgen receptor expression and tissue properties may lead to higher cryptorchidism risk in certain rats.

Modified steroidal inhibitors showed promise in treating hormone-dependent cancers.

Retinoic acid affects skin and hair health by working with specific receptors, and its absence can lead to hair loss and skin changes.

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

High amphiregulin in the skin is a bad sign for acute graft-versus-host disease.