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Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Mutations in the LSS gene cause hair loss and may affect brain development, with varying severity.

A unique enzyme in guinea pig hair follicles helps form protein cross-links in hair.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

A novel CLDN1 mutation in a 2-month-old with NISCH showed improvement with symptom management.

CAP1/Prss8 does not activate PAR2 or inhibit PN-1.

Increased methylation of the Filip1l gene may contribute to aggressive skin cancer.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Certain changes in the KAP6-1 gene affect the thickness and length of cashmere goat fibers.

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

Phospholipase A2 enzymes play key roles in skin health and disease.

A new mutation in the HJV gene was found in a young woman with juvenile hemochromatosis, causing unusual symptoms like secondary hypothyroidism.

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.

Cathepsin L deficiency causes hair and skin issues in mice.

A bull with a gene mutation was asymptomatic, synthetic retinoids cause hair loss, and new therapeutic targets were identified for skin diseases.

CRISPR gene editing reduces harmful molecules in cells from Emery–Dreifuss Muscular Dystrophy patients.

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

C-scores can help predict gain-of-function and loss-of-function mutations.

Researchers found a new mutation in the EDA gene that likely causes missing teeth and mild skin symptoms in one family.

XEDAR deficiency prevents muscle degeneration in EDA-A2 transgenic mice.

A specific DNA pattern in Malassezia restricta may be linked to hair loss in men.

Removing certain hair follicle stem cells worsens skin reactions to allergens.

Certain genetic markers on the Y-chromosome may influence prostate cancer risk in Iraqi males.

A new mutation in mice causes crooked whiskers and messy hair.

The study mapped keratin 15 and 19 genes, aiding future genetic disorder research.

Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.