June 2016 in “Experimental Dermatology” Changing hair follicle identity could potentially reverse balding.
4 citations
,
July 2020 in “Biochemical and Biophysical Research Communications” A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.
46 citations
,
June 1983 in “Cleveland Clinic Journal of Medicine” Higher DHEAS levels may cause hair loss in women by disrupting hair growth.
205 citations
,
March 2012 in “Science Translational Medicine” PGD2 stops hair growth and is higher in bald men with AGA.
19 citations
,
September 2011 in “Journal of Dermatological Science” TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.
10 citations
,
November 1997 in “British Journal of Dermatology” RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.
Minoxidil can slow hair loss and promote regrowth but won't fully restore hair.
May 2017 in “Journal of The American Academy of Dermatology” The treatment increased hair follicle counts and is potentially effective for male hair loss without serious side effects.
February 2015 in “American journal of medical and biological research” Balding hair follicles have less growth-promoting factors and more inhibitory factors, leading to hair loss.
1 citations
,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
7 citations
,
January 1981 in “Springer eBooks” The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.
196 citations
,
March 2016 in “Nature Communications” Genetic factors influence hair traits like shape, color, and greying in Latin Americans.
139 citations
,
July 1991 in “Journal of The American Academy of Dermatology” Understanding hair follicle anatomy helps diagnose hair disorders.
126 citations
,
January 2009 in “International Journal of Trichology” Oxidative stress contributes to hair graying and loss as we age.
22 citations
,
May 2002 in “Skin Research and Technology” CE-PTG detects early hair follicle issues in balding areas, helping measure male hair loss.
14 citations
,
May 2019 in “Journal of Maxillofacial and Oral Surgery” FUE hair transplant is a promising method with benefits like less scarring, but requires a skilled surgeon and can damage hair follicles.
6 citations
,
January 2022 in “Journal of Investigative Dermatology” Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.
4 citations
,
December 2020 in “Journal of Dermatology” Impaired autophagy may cause hair loss by triggering early catagen.
1 citations
,
October 1996 in “Dermatologic clinics” Adiponectin reduces inflammation and bone loss in joint replacements.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Hair loss is caused by mechanical, thermal, and metabolic factors, not just hormones.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Hair loss is caused by mechanical, thermal, and metabolic stress, not just hormones.
January 2015 in “Springer eBooks” Hair health is influenced by genetics, aging, and environmental factors, with proper care needed to maintain it.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
August 2007 in “CRC Press eBooks” Hair loss is mainly caused by a testosterone byproduct, and hair restoration surgery uses hair from the back and sides of the scalp.
TGF-β1 and 2 in hair follicles may be linked to hair loss in AGA.
18 citations
,
July 2016 in “Medicine” Wnt/β-catenin and TGF-β pathways affect hair loss, and activating Wnt/β-catenin could be a potential treatment.
October 2003 in “Journal of the Royal Society of Medicine” The book is a detailed guide on hair diseases and diagnosis, useful for skin disease experts.
2 citations
,
July 2018 in “Journal of Cosmetic Dermatology” Common latent viruses might contribute to male-pattern baldness by disrupting cell processes that normally suppress hair loss-related proteins.
February 2011 in “Expert Review of Dermatology” Researchers found potential new targets for treating melanoma and nonmelanoma skin cancers, and identified a possible cause and treatment for male pattern baldness and eczema.
AGA is caused by genetics and androgens, treatable with finasteride and minoxidil.