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GlossaryBarrier Function

skin's defense against environmental threats and moisture loss

The barrier function refers to the skin's ability to act as a protective shield against environmental aggressors, such as pathogens, chemicals, and physical injuries. It involves the outermost layer of the skin, known as the stratum corneum, which maintains hydration and prevents the entry of harmful substances. This function is crucial for overall skin health and integrity, and its impairment can lead to conditions like eczema and increased susceptibility to infections.

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Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

Lipid Losses and Barrier Function Modifications of the Brown-to-White Hair Transition

research Lipid loses and barrier function modifications of the brown‐to‐white hair transition

12 citations , February 2019 in “Skin research and technology”

White hair has less lipid content and absorbs water differently than brown hair.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations , August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

research The Role of PGC-1α in Aging Skin Barrier Function

8 citations , July 2024 in “Cells”

PGC-1α may improve aging skin by boosting mitochondrial function and reducing inflammation.

research 371 Hair follicles are critical modulators of skin barrier function

July 2024 in “Journal of Investigative Dermatology”

Hair follicles are crucial for maintaining skin barrier function.

research Epithelial barrier function: assembly and structural features of the cornified cell envelope

425 citations , August 2002 in “BioEssays”

The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.

research Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

84 citations , May 2008 in “Biological Chemistry”

Human tissue kallikreins help regulate skin barrier functions and affect skin health.

research Caffeine improves barrier function in male skin

33 citations , September 2006 in “International Journal of Cosmetic Science”

Caffeine improves male skin's barrier function.

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

31 citations , July 2012 in “Journal of Lipid Research”

ACBP is crucial for healthy skin in mice.

research TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function

22 citations , September 2011 in “Journal of Investigative Dermatology”

TCF/Lef1 is essential for skin barrier function by regulating lipid metabolism.

research The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss

19 citations , March 2017 in “Scientific Reports”

HAT-L4 is crucial for preventing body fluid loss by maintaining skin barrier integrity.

research Acyl-CoA binding protein and epidermal barrier function

15 citations , March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.

research Hair follicles modulate skin barrier function

9 citations , June 2024 in “Cell Reports”

Hair follicles play a crucial role in regulating skin barrier function.

research The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function

1 citations , January 2013

Glucosylceramides are essential for healthy skin and proper wound healing.

research 415 Targeting inflammation and specialized pro-resolving mediators to reinforce barrier function and scalp homeostasis.

November 2022 in “Journal of Investigative Dermatology”

Targeting inflammation can improve scalp and hair health.

research The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function)

August 2015 in “Free Radical Biology and Medicine”

Nrf2 helps protect skin from damage but too much can cause skin problems.

research Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin

8 citations , December 2024 in “Frontiers in Medicine”

Damaged skin has a weakened barrier, making it more vulnerable to substances and inflammation.

research The stratum corneum barrier: impaired function in relation to associated lipids and proteins

7 citations , May 2024 in “Tissue Barriers”

The skin's outer layer relies on lipids and proteins to protect against damage.

research The role of tight junctions in skin barrier function and dermal absorption

156 citations , August 2016 in “Journal of controlled release”

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis

1 citations , March 2024 in “International journal of molecular sciences”

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

research Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling

2 citations , August 2023 in “Molecules”

SH-340 may improve skin barrier and help treat atopic dermatitis.

research 732 Ceramide synthase 4 controls epidermal lipid composition and barrier function

April 2018 in “Journal of Investigative Dermatology”

Ceramide synthase 4 is essential for maintaining skin barrier health.

Considering the Risk of Coloring Shampoo for Gray Hair Cover in Cosmetology and Skin Barrier: A Systematic Review

research Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review

May 2023 in “Health science reports”

Coloring shampoos for gray hair may cause gene mutation, reproductive issues, and skin damage, needing stricter regulation and expert consultation.

Hair Follicle Stem Cells and the Collapse of Self-Tolerance in Alopecia: The Interplay of Barrier Function, the Microbiome, and Immunity

research Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity

November 2024 in “EMBO Molecular Medicine”

JAK inhibitors may reverse early hair loss, but prolonged inflammation can cause permanent hair loss.

research 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Esrp1 is important for skin health by helping form and maintain the skin barrier.

research 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions

April 2017 in “Journal of Investigative Dermatology”

Applying pseudoceramide improved skin and hair health.

research 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function

September 2017 in “Journal of Investigative Dermatology”

Activating the hexosamine pathway can improve skin health and increase hair follicle stem cells.

research Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

324 citations , May 2002 in “Oncogene”

research Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

195 citations , November 2001 in “The Journal of Cell Biology”

Desmocollin 1 is essential for strong skin and proper skin function.