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4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

research 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production

11 citations , March 2009 in “Bioorganic & Medicinal Chemistry Letters”

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

research Unsaturated Halogenated Hydrocarbons

1 citations , March 2004 in “Patty's Toxicology”

These chemicals can be toxic, causing health issues like cancer, liver damage, and irritation.

research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond

2 citations , December 2008 in “Journal of Chemical Crystallography”

The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.

research Selective isomerization of α-pinene oxide to campholenic aldehyde by ionic liquid-supported indenyl-molybdenum(II)-bipyridine complexes

6 citations , May 2022 in “Journal of Organometallic Chemistry”

The process efficiently converts α-pinene oxide to campholenic aldehyde using a special catalyst, achieving high yields quickly.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

research Reaction of Finasteride Intermediate with Benzeneseleninic Anhydride: An In-Depth Study

2 citations , November 2008 in “Industrial & Engineering Chemistry Research”

Impure benzeneseleninic anhydride samples cause lower finasteride intermediate yields.

research Unsaturated Halogenated Hydrocarbons

1 citations , March 2004 in “Patty's Toxicology”

These chemicals can be toxic and cause health issues like irritation, liver damage, and cancer.

Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety

7 citations , August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research Synthesis of mimics of steroid A ring as potential enzyme inhibitors

September 2002 in “Research Repository (Kingston University London)”

Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Crystal Structure and Synthesis of 17α-Acetoxy-4-bromopregn-4-ene-3,20-dione

August 2002 in “Analytical Sciences”

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

research Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues

8 citations , January 2013 in “Medicinal chemistry”

The compound 4c showed strong potential as an anticancer agent.

research Evaluation of carcinogenic effect of mineral oil used in the processing of jute fibres.

8 citations , October 1979 in “PubMed”

Jute-batching oil alone didn't cause cancer in mice, but it may promote cancer when combined with another carcinogen.

research Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production

7 citations , April 2009 in “Bioorganic & Medicinal Chemistry Letters”

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione

2 citations , October 2001 in “Analytical Sciences”

A new compound that could treat various androgen-related conditions was created and analyzed.

research Phytochemical study of Bituminaria basaltica aerial parts, an Italian endemism

5 citations , March 2017 in “Natural Product Research”

Researchers found eight natural compounds and essential oils in the Italian plant Bituminaria basaltica, which are typical for its genus and known for bioactivity.

research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors

May 2022 in “Current Enzyme Inhibition”

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

research Tumors Of The Pilosebaceous Unit Induced In The Rat By The Intravenous Administration Of 7, 12-Dimethylbenz[A]Anthracene

6 citations , March 1976 in “Journal of Investigative Dermatology”

research The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

August 2021 in “Research Square (Research Square)”

Borneol Essential Oil could be a natural and safe acne treatment.

research Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives

March 2024 in “Organic letters”

A new method efficiently modifies alkenes to create useful medicinal compounds.

research Computational Evaluation of Dibenzo Compounds as Potential Dual Inhibitors of Androgen Receptor and 5α-Reductase

January 2022 in “Asian journal of Current Research in Clinical Cancer”

Some dibenzo compounds might help treat cancer with fewer side effects.

research Theoretical investigation of the conformational space of baicalin

3 citations , July 2017 in “Journal of Molecular Graphics & Modelling”

The study found that baicalin has different stable shapes in gas and water, with two shapes better for interacting with positive charges in water.

research Tuning Scaffold Properties of New 1,4-Substituted Pyrrolo[3,2-c]quinoline Derivatives Endowed with Anticancer Potential, New Biological and In Silico Insights

December 2025 in “Biomolecules”

Compound 7p shows strong potential as an anticancer agent.

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring

20 citations , September 2005 in “Endocrinology”

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

research HPLC-ESI-MSn characterization of phenolic compounds, terpenoid saponins, and other minor compounds in Bituminaria bituminosa

76 citations , February 2015 in “Industrial Crops and Products”

Researchers found over 40 compounds in Bituminaria bituminosa, including many flavonoids and some with potential for medical and hair care uses.

research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping

10 citations , November 2017 in “Letters in drug design & discovery”

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

research Finasteride 98319‐26‐7

October 2012 in “Sax's Dangerous Properties of Industrial Materials”

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

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