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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors

April 1992 in “Current opinion in therapeutic patents”

New steroids were patented as effective for treating acne, hair loss, and other conditions related to hormones.

research Dependence of anxiolytic effects of the dipeptide TSPO ligand GD-23 on neurosteroid biosynthesis

6 citations , July 2016 in “Doklady Biochemistry and Biophysics”

GD-23 reduces anxiety by relying on neurosteroid production.

research Crystal Structure and Synthesis of 17α-Acetoxy-4-bromopregn-4-ene-3,20-dione

August 2002 in “Analytical Sciences”

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

research Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

11 citations , May 2010 in “Journal of Medicinal Chemistry”

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

research Antipsychotic-Like Properties of 5-α-Reductase Inhibitors

64 citations , March 2008 in “Neuropsychopharmacology”

research ChemInform Abstract: Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α‐Reductase Inhibitor.

April 2011 in “ChemInform”

A new compound may effectively inhibit the enzyme linked to BPH and hair loss.

research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors

20 citations , March 2005 in “Current Medicinal Chemistry”

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

research Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation

6 citations , August 2024 in “Advanced Science”

A new method efficiently creates biaryl N-oxides with potential for cancer treatment and drug development.

Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

November 2023

New steroid derivatives show promise as anticancer agents, even against resistant cells.

research Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

29 citations , November 2021 in “FEBS Open Bio”

Cepharanthine analogues, especially tetrandrine, show potential for treating COVID-19.

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

Scientists made two new chemicals that might help treat diseases caused by male hormones.

research Patent Evaluation: Hexahydrobenzo[f]quinolines as 5α-reductase inhibitors

June 1993 in “Current opinion in therapeutic patents”

Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.

Crystal Structure and Synthesis of 17α-Acetoxy-6,7-Epoxypregn-4-ene-3,20-dione

research Crystal Structure and Synthesis of 17.ALPHA.-Acetoxy-6,7-epoxypregn-4-ene-3,20-dione

1 citations , January 2009 in “X-ray Structure Analysis Online”

A new compound was made that might help treat diseases related to male hormones.

Novel Progestogenic Androgens for Male Contraception: Design, Synthesis, and Activity of C7 Alpha-Substituted Testosterone

research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

September 2023 in “Biology of reproduction”

New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.

research Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues

8 citations , January 2013 in “Medicinal chemistry”

The compound 4c showed strong potential as an anticancer agent.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione

2 citations , October 2001 in “Analytical Sciences”

A new compound that could treat various androgen-related conditions was created and analyzed.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors

14 citations , June 2011 in “Steroids”

New compounds may help treat prostate issues without affecting androgen receptors.

research Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone

8 citations , October 2013 in “Chemistry Central Journal”

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Summary of Findings on Psychotropic Medications

research Table of Contents

December 2006 in “The Brown University Psychopharmacology Update”

Second-generation antipsychotics offer no significant benefit over first-generation ones for schizophrenia.

research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs

1 citations , February 2014 in “Archiv Der Pharmazie”

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

research A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives

2 citations , May 2020 in “Molecules”

A new, efficient method was developed to synthesize a specific compound and its derivatives.

Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3

research Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3

15 citations , April 2008 in “Steroids”

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

research Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors

October 2019

New pyridine compounds effectively inhibit GSK3, a diabetes treatment target.

research Effect of flutamide and two novel synthetic steroids on GABA, glutamine and some oxidative stress markers in rat brain and prostate

2 citations , January 2011 in “Andrologia”

Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.

research Non-competitive androgen receptor inhibition in vitro and in vivo

January 2010 in “Yearbook of Endocrinology”

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

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